Mobilization of natural killer cells inhibits development of collagen-induced arthritis

Leavenworth J.W.; Wang X.; Wenander C.S.Spee P.Cantor H.

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Mobilization of natural killer cells inhibits development of collagen-induced arthritis

机译：Mobilization of natural killer cells inhibits development of collagen-induced arthritis

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Although natural killer (NK) cells have been implicated in regulating immune responses, their ability to modulate disease development in autoimmune arthritis has not been analyzed. Here we investigate the contribution of NK cells to regulating collagen-induced arthritis, a well-characterized preclinical model of human rheumatoid arthritis. We find that the disease is induced by the combined action of two CD4~+ T helper (T_H) subsets: follicular T_H cells and T_H17 cells. Both CD4~+ T_H subsets are highly susceptible to lysis by NK cells after activation. Administration of antibody that activates NK cells through blockade of its inhibitory CD94/NKG2A receptor allows enhanced elimination of pathogenic follicular T_H and T_H17 cells and arrest of disease progression. These results suggest that antibody- dependent enhancement of NK activity may yield effective, previously undescribed therapeutic approaches to this autoimmune disorder.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2011年第35期|14584-14589|共6页
作者
Leavenworth J.W.; Wang X.; Wenander C.S.Spee P.Cantor H.;
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作者单位

Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA 02115, United States;

Department of Immunopharmacology, Novo Nordisk A/S, DK-2760 M?l?v, Denmark;

Department of Translational Immunology, Novo Nordisk A/S, DK-2760 M?l?v, Denmark;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Antibody therapy; Qa-1; T helper subsets;

Mobilization of natural killer cells inhibits development of collagen-induced arthritis

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