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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Basal NF-κB controls IL-7 responsiveness of quiescent na?ve T cells
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Basal NF-κB controls IL-7 responsiveness of quiescent na?ve T cells

机译：Basal NF-κB controls IL-7 responsiveness of quiescent na?ve T cells

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摘要

T cells are essential for immune defenses against pathogens, such that viability of na?ve T cells before antigen encounter is critical to preserve a polyclonal repertoire and prevent immunodeficiencies. The viability of na?ve T cells before antigen recognition is ensured by IL-7, which drives expression of the prosurvival factor Bcl-2. Quiescent na?ve T cells have low basal activity of the transcription factor NF-κB, which was assumed to have no functional consequences. In contrast to this postulate, our data show that basal nuclear NF-κB activity plays an important role in the transcription of IL-7 receptor α-subunit (CD127), enabling responsiveness of na?ve T cells to the prosurvival effects of IL-7 and allowing T-cell persistence in vivo. Moreover, we show that this property of basal NF-κB activity is shared by mouse and human na?ve T cells. Thus, NF-κB drives a distinct transcriptional program in T cells before antigen encounter by controlling susceptibility to IL-7. Our results reveal an evolutionarily conserved role of NF-κB in T cells before antigenic stimulation and identify a novel molecular pathway that controls T-cell homeostasis.

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