MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life

Lin Quan; Ponnusamy Ravikumar; Widagdo JocelynChoi Jung A.Ge WeihongProbst ChristineBuckley TylerLou MimiBredy Timothy W.Fanselow Michael S.Ye KeqiangSun Yi E.

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America. >MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life

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MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life

机译：MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life

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The prenatal period of cortical development is important for the establishment of neural circuitry and functional connectivity of the brain; however, the molecular mechanisms underlying this process remain unclear. Here we report that disruption of the actin-cytoskeletal network in the developing mouse prefrontal cortex alters dendritic morphogenesis and synapse formation, leading to enhanced formation of fear-related memory in adulthood. These effects are mediated by a brain-enriched microRNA, miR-9, through its negative regulation of diaphanous homologous protein 1 (Diap1), a key organizer of the actin cytoskeletal assembly. Our findings not only revealed important regulation of dendritogenesis and synaptogenesis during early brain development but also demonstrated a tight link between these early developmental events and cognitive functions later in life.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2017年第34期|9188-9193|共6页
作者
Lin Quan; Ponnusamy Ravikumar; Widagdo JocelynChoi Jung A.Ge WeihongProbst ChristineBuckley TylerLou MimiBredy Timothy W.Fanselow Michael S.Ye KeqiangSun Yi E.;
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作者单位

Univ Southern Calif, Sch Pharm, Los Angeles, CA 90033 USA;

Univ Queensland, Queensland Brain Inst, Brisbane, Qld 4072, Australia;

Univ Calif Los Angeles, Dept Psychiat & Behav Sci, Intellectual Dev & Disabil Res Ctr, Los Angeles, CA 90095 USAEmory Univ, Sch Med, Dept Pathol & Lab Med, Ctr Neurodegenerat Dis, Atlanta, GA 30322 USATongji Univ, Sch Med, Tongji Hosp, Stem Cell Translat Res Ctr, Shanghai 200092, Peoples R ChinaStanford Univ, Sch Med, Dept Psychiat, Vet Affairs Palo Alto Div, Palo Alto, CA 94304 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
miR-9; learning; memory; Diap1; dendritogenesis;

MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life

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