A functional genomic perspective on human well-being

Fredrickson B.L.; Grewen K.M.; Coffey K.A.Algoe S.B.Firestine A.M.Arevalo J.M.G.Ma J.Cole S.W.

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A functional genomic perspective on human well-being

机译：A functional genomic perspective on human well-being

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To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounded negative psychological and behavioral factors. Hedonic and eudaimonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people with high levels of hedonic well-being showed up-regulated expression of a stress-related conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes and decreased expression of genes involved in antibody synthesis and type I IFN response. In contrast, high levels of eudaimonic well-being were associated with CTRA down-regulation. Promoter-based bioinformatics implicated distinct patterns of transcription factor activity in structuring the observed differences in gene expression associated with eudaimonic well-being (reduced NF-?B and AP-1 signaling and increased IRF and STAT signaling). Transcript origin analysis identified monocytes, plasmacytoid dendritic cells, and B lymphocytes as primary cellular mediators of these dynamics. The finding that hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar effects on total well-being and depressive symptoms implies that the human genome may be more sensitive to qualitative variations in well-being than are our conscious affective experiences.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第33期|13684-13689|共6页
作者
Fredrickson B.L.; Grewen K.M.; Coffey K.A.Algoe S.B.Firestine A.M.Arevalo J.M.G.Ma J.Cole S.W.;
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作者单位

Department of Psychology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States;

Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC 27599, United States;

University of California Los Angeles, School of Medicine, Los Angeles, CA 90095, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Gene regulation; Social genomics;

A functional genomic perspective on human well-being

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