The Mohawk homeobox gene is a critical regulator of tendon differentiation

Ito Y.; Toriuchi N.; Yoshitaka T.Ueno-Kudoh H.Sato T.Yokoyama S.Nishida K.Akimoto T.Takahashi M.Miyaki S.Asahara H.

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The Mohawk homeobox gene is a critical regulator of tendon differentiation

机译：The Mohawk homeobox gene is a critical regulator of tendon differentiation

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摘要

Mohawk(Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx~(-/-) mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx~(-/-) mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx~(-/-) tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2010年第23期|10538-10542|共5页
作者
Ito Y.; Toriuchi N.; Yoshitaka T.Ueno-Kudoh H.Sato T.Yokoyama S.Nishida K.Akimoto T.Takahashi M.Miyaki S.Asahara H.;
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作者单位

Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan;

Department of Human Morphology, Okayama University, Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan;

Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
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The Mohawk homeobox gene is a critical regulator of tendon differentiation

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