CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats

George  O; Ghozland  S; Azar  MRCottone  PZorrilla  EPParsons  LHODell  LERichardson  HNKoob  GF

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CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats

机译：CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats

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摘要

Nicotine, the main psychoactive ingredient of tobacco, induces negative emotional symptoms during abstinence that contribute to a profound craving for nicotine. However, the neurobiological mechanisms underlying how nicotine produces dependence remains poorly understood. We demonstrate one mechanism for both the anxiety-like symptoms of withdrawal and excessive nicotine intake observed after abstinence, through recruitment of the extra hypothalamic stress peptide corticotropin-releasing factor (CRF) system and activation of CRF, receptors. Overactivation of the CRF-CRF1 system may contribute to nicotine dependence and may represent a prominent target for investigating the vulnerability to tobacco addiction.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2007年第43期|17198-17203|共6页
作者
George O; Ghozland S; Azar MRCottone PZorrilla EPParsons LHODell LERichardson HNKoob GF;
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作者单位

Scripps Res Inst, Comm Neurobiol Addict Disorders, La Jolla, CA 92037 USA;

Univ Texas, Dept Psychol, El Paso, TX 79968 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
abstinence; addiction; amygdala; deprivation; stress; CORTICOTROPIN-RELEASING-FACTOR; ELEVATED PLUS-MAZE; TOBACCO DEPENDENCE; COCAINE WITHDRAWAL; CIGARETTE-SMOKING; DRUG-WITHDRAWAL; CENTRAL NUCLEUS; BRAIN; AMYGDALA; ANXIETY;

CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats

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