Osteoclast precursors in murine bone marrow express CD27 and are impeded in osteoclast development by CD70 on activated immune cells

Xiao Y.; Song J.-Y.; De Vries T.J.Fatmawati C.Parreira D.B.Langenbach G.E.J.Babala N.Nolte M.A.Everts V.Borst J.

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Osteoclast precursors in murine bone marrow express CD27 and are impeded in osteoclast development by CD70 on activated immune cells

【24h】

Osteoclast precursors in murine bone marrow express CD27 and are impeded in osteoclast development by CD70 on activated immune cells

机译：Osteoclast precursors in murine bone marrow express CD27 and are impeded in osteoclast development by CD70 on activated immune cells

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Osteoclasts (OCs) are bone-resorbing cells that are formed from hematopoietic precursors. OCs ordinarily maintain bone homeostasis, but they can also cause major pathology in autoimmune and inflammatory diseases. Under homeostatic conditions, receptor activator of nuclear factor kappa-B (RANK) ligand on osteoblasts drives OC differentiation by interaction with its receptor RANK on OC precursors. During chronic immune activation, RANK ligand on activated immune cells likewise drives pathogenic OC differentiation. We here report that the related TNF family member CD70 and its receptor CD27 can also mediate cross-talk between immune cells and OC precursors. We identified CD27 on a rare population (0.3) of B220-c-Kit+CD115+CD11blow cells in the mouse bone marrow (BM) that are highly enriched for osteoclastogenic potential. We dissected this population into CD27high common precursors of OC, dendritic cells (DCs) and macrophages and CD27low/neg downstream precursors that could differentiate into OC and macrophages, but not DC. In a recombinant mouse model of chronic immune activation, sustained CD27/CD70 interactions caused an accumulation of OC precursors and a reduction in OC activity. These events were due to a CD27/CD70-dependent inhibition of OC differentiation from the OC precursors by BM-infiltrating, CD70+-activated immune cells. DC numbers in BM and spleen were increased, suggesting a skewing of the OC precursors toward DC differentiation. The impediment in OC differentiation culminated in a high trabecular bone mass pathology. Mice additionally presented anemia, leukopenia, and splenomegaly. Thus, under conditions of constitutive CD70 expression reflecting chronic immune activation, the CD27/CD70 system inhibits OC differentiation and favors DC differentiation.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第30期|12385-12390|共6页
作者
Xiao Y.; Song J.-Y.; De Vries T.J.Fatmawati C.Parreira D.B.Langenbach G.E.J.Babala N.Nolte M.A.Everts V.Borst J.;
展开▼
作者单位

Division of Immunology, Netherlands Cancer Institute, 1066 CX, Amsterdam, Netherlands;

Department of Animal Pathology, Netherlands Cancer Institute, 1066 CX, Amsterdam, Netherlands;

Departments of Periodontology, NetherlandsDepartment of Hematopoiesis, Sanquin Research, 1066 CX, Amsterdam, Netherlands;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Costimulation; Hematopoiesis; Osteoimmunology; TNF receptor family;

Osteoclast precursors in murine bone marrow express CD27 and are impeded in osteoclast development by CD70 on activated immune cells

摘要

著录项

相关主题

期刊订阅