Electronic cigarettes aerosolize e-liquids, mixtures of vegetable glycerin (VG), propylene glycol (PG), nicotine, and flavorings, with a heated metal coil. Since their introduction in the early 21st century, e-cigarettes have increased dramatically in popularity and have undergone technological evolution in multiple directions, becoming a multibillion-dollar industry. The variety of devices and e-liquids available in vape shops and online is extraordinary, presenting formidable challenges to scientists, health care practitioners, and policymakers.
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