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首页> 外文期刊>Bioorganic and medicinal chemistry >Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity.
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Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity.

机译:Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity.

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摘要

Based on anti-viral screening of our heteroaromatics derived from thalidomide, the gamma-carboline skeleton has been identified as a superior scaffold structure for compounds with potent anti-bovine viral diarrhea virus (BVDV) activity. Structural development studies led to a potent anti-viral agent, SK5M (5-methyl-gamma-carboline), with the EC(50) of 0.26 microM.

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