Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer

Stritzker J.; Kirscher L.; Scadeng M.Deliolanis N.C.Morscher S.Symvoulidis P.Schaefer K.Zhang Q.Buckel L.Hess M.Donat U.Bradley W.G.Ntziachristos V.Szalay A.A.

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Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer

机译：Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer

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We reported earlier the delivery of antiangiogenic single chain antibodies by using oncolytic vaccinia virus strains to enhance their therapeutic efficacy. Here, we provide evidence that gene-evoked production of melanin can be used as a therapeutic and diagnostic mediator, as exemplified by insertion of only one or two genes into the genome of an oncolytic vaccinia virus strain.We found that produced melanin is an excellent reporter for optical imaging without addition of substrate.Melanin production also facilitated deep tissue optoacoustic imaging as well asMRI. In addition,melanin was shown to be a suitable target for laser-induced thermotherapy and enhanced oncolytic viral therapy. In conclusion, melanin as a mediator for thermotherapy and reporter for different imaging modalities may soon become a versatile alternative to replace fluorescent proteins also in other biological systems. After ongoing extensive preclinical studies, melanin overproducing oncolytic virus strainsmight be used in clinical trials in patients with cancer.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第9期|3316-3320|共5页
作者
Stritzker J.; Kirscher L.; Scadeng M.Deliolanis N.C.Morscher S.Symvoulidis P.Schaefer K.Zhang Q.Buckel L.Hess M.Donat U.Bradley W.G.Ntziachristos V.Szalay A.A.;
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作者单位

Genelux, San Diego, CA 92109, United States;

Department of Biochemistry, Biocenter, University of Würzburg, 97074 Würzburg, Germany;

Center for Functional MRI, University of California at San Diego, San Diego, CA 92093, United StatesInstitute for Biological and Medical Imaging, Helmholtz Zentrum München and Technische Universit?t München, 85764 Neuherberg, GermanyDepartment of Radiology, University of California at San Diego Medical Center, San Diego, CA 92103, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Diagnosis; Personalized medicine; Photoacoustic; Translational medicine; Whole-body imaging;

Vaccinia virus-mediated melanin production allows MR and optoacoustic deep tissue imaging and laser-induced thermotherapy of cancer

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