Physiological role for amyloid precursor protein in adult experience-dependent plasticity

Marik Sally A.; Olsen Olav; Tessier-Lavigne MarcGilbert Charles D.

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Physiological role for amyloid precursor protein in adult experience-dependent plasticity

机译：Physiological role for amyloid precursor protein in adult experience-dependent plasticity

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摘要

Changes in neural circuits after experience-dependent plasticity are brought about by the formation of new circuits via axonal growth and pruning. Here, using a combination of electrophysiology, adeno-associated virus-delivered fluorescent proteins, analysis of mutant mice, and two-photon microscopy, we follow long-range horizontally projecting axons in primary somatosensory cortex before and after selective whisker plucking. Whisker plucking induces axonal growth and pruning of horizontal projecting axons from neurons located in the surrounding intact whisker representations. We report that amyloid precursor protein is crucial for axonal pruning and contributes in a cell autonomous way.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2016年第28期|7912-7917|共6页
作者
Marik Sally A.; Olsen Olav; Tessier-Lavigne MarcGilbert Charles D.;
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作者单位

Rockefeller Univ, Neurobiol Lab, New York, NY 10065 USA;

Rockefeller Univ, Lab Brain Dev & Repair, New York, NY 10065 USA;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
axon pruning; long-range axons; amyloid precursor protein; somatosensory cortex; experience-dependent plasticity;

Physiological role for amyloid precursor protein in adult experience-dependent plasticity

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