Longitudinal four-dimensional mapping of subcortical anatomy in human development

Armin Raznahan; Phillip W. Shaw; Jason P. LerchLiv S. ClasenDeanna GreensteinRebecca BermanJon PipitoneMallar M. ChakravartyJay N. Giedd

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Longitudinal four-dimensional mapping of subcortical anatomy in human development

机译：Longitudinal four-dimensional mapping of subcortical anatomy in human development

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Growing access to large-scale longitudinal structural neuroimaging data has fundamentally altered our understanding of cortical development en route to human adulthood, with consequences for basic science, medicine, and public policy. In striking contrast, basic anatomical development of subcortical structures such as the striatum, pallidum, and thalamus has remained poorly described--despite these evolutionarily ancient structures being both intimate working partners of the cortical sheet and critical to diverse developmentally emergent skills and disorders. Here, to begin addressing this disparity, we apply methods for the measurement of subcortical volume and shape to 1,171 longitudinally acquired structural magnetic resonance imaging brain scans from 618 typically developing males and females aged 5-25 y. We show that the striatum, pallidum, and thalamus each follow curvilinear trajectories of volume change, which, for the striatum and thalamus, peak after cortical volume has already begun to decline and show a relative delay in males. Four-dimensional mapping of subcortical shape reveals that (i) striatal, pallidal, and thalamic domains linked to specific fronto-parietal association cortices contract with age whereas other subcortical territories expand, and (ii) each structure harbors hotspots of sexually dimorphic change over adolescence--with relevance for sex-biased mental disorders emerging in youth. By establishing the developmental dynamism, spatial heterochonicity, and sexual dimorphism of human subcortical maturation, these data bring our spatiotemporal understanding of subcortical development closer to that of the cortex--allowing evolutionary, basic, and clinical neuroscience to be conducted within a more comprehensive developmental framework.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第4期|1592-1597|共6页
作者
Armin Raznahan; Phillip W. Shaw; Jason P. LerchLiv S. ClasenDeanna GreensteinRebecca BermanJon PipitoneMallar M. ChakravartyJay N. Giedd;
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作者单位

Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892;

Neurobehavioral Clinical Research Section, Social and Behavioral Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;

Kimel Family Imaging-Genetic Research Laboratory, Centre for Addiction and Mental Health, Toronto, ON, Canada M5T 1R8Department of Psychiatry and Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada M5T 1R8;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Longitudinal; subcortical anatomy; human development;

Longitudinal four-dimensional mapping of subcortical anatomy in human development

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