Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice

Shah R. Ali; Simon Hippenmeyer; Lily V. SaadatLiqun LuoIrving L. WeissmanReza Ardehali

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Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice

机译：Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice

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The mammalian heart has long been considered a postmitotic organ, implying that the total number of cardiomyocytes is set at birth. Analysis of cell division in the mammalian heart is complicated by cardiomyocyte binucleation shortly after birth, which makes it challenging to interpret traditional assays of cell turnover Laflamme MA, Murray CE (2011) Nature 473(7347):326–335;Bergmann O, et al. (2009) Science 324(5923):98–102. An elegant multi-isotope imaging-mass spectrometry technique recently calculated the low, discrete rate of cardiomyocyte generation in mice Senyo SE, et al. (2013) Nature 493(7432):433–436, yet our cellularlevel understanding of postnatal cardiomyogenesis remains limited. Herein, we provide a new line of evidence for the differentiated α-myosin heavy chain-expressing cardiomyocyte as the cell of origin of postnatal cardiomyogenesis using the "mosaic analysis with double markers" mouse model. We show limited, life-long, symmetric division of cardiomyocytes as a rare event that is evident in utero but significantly diminishes after the first month of life in mice;daughter cardiomyocytes divide very seldom, which this study is the first to demonstrate, to our knowledge. Furthermore, ligation of the left anterior descending coronary artery, which causes a myocardial infarction in the mosaic analysis with double-marker mice, did not increase the rate of cardiomyocyte division above the basal level for up to 4 wk after the injury. The clonal analysis described here provides direct evidence of postnatal mammalian cardiomyogenesis.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第24期|8850-8855|共6页
作者
Shah R. Ali; Simon Hippenmeyer; Lily V. SaadatLiqun LuoIrving L. WeissmanReza Ardehali;
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作者单位

Department of Internal Medicine, Division of Cardiology,University of California at Los Angeles School of Medicine, Los Angeles, CA, 90095;

Departments of Pathology and Developmental Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305;

Department of Biology,Stanford University, Stanford, CA 94305;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
heart development; cardiovascular progenitors; aging; regeneration;

Existing cardiomyocytes generate cardiomyocytes at a low rate after birth in mice

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