Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding

de Wael Reinder Vos; Lariviere Sara; Caldairou BenoitHong Seok-JunMargulies Daniel S.Jefferies ElizabethBernasconi AndreaSmallwood JonathanBernasconi NedaBernhardt Boris C.

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Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding

机译：Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding

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The hippocampus plays key roles in cognition and affect and serves as a model system for structure/function studies in animals. So far, its complex anatomy has challenged investigations targeting its substructural organization in humans. State-of-the-art MRI offers the resolution and versatility to identify hippocampal subfields, assess its microstructure, and study topographical principles of its connectivity in vivo. We developed an approach to unfold the human hippocampus and examine spatial variations of intrinsic functional connectivity in a large cohort of healthy adults. In addition to mapping common and unique connections across subfields, we identified two main axes of subregional connectivity transitions. An anterior/posterior gradient followed long-axis landmarks and metaanalytical findings from task-based functional MRI, while a medial/lateral gradient followed hippocampal infolding and correlated with proxies of cortical myelin. Findings were consistent in an independent sample and highly stable across resting-state scans. Our results provide robust evidence for long-axis specialization in the resting human hippocampus and suggest an intriguing interplay between connectivity and microstructure.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2018年第40期|10154-10159|共6页
作者
de Wael Reinder Vos; Lariviere Sara; Caldairou BenoitHong Seok-JunMargulies Daniel S.Jefferies ElizabethBernasconi AndreaSmallwood JonathanBernasconi NedaBernhardt Boris C.;
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作者单位

McGill Univ, McConnell Brain Imaging Ctr, Montreal Neurol Inst, Multimodal Imaging & Connectome Anal Lab, Montreal, PQ H3A 2B4, Canada;

McGill Univ, McConnell Brain Imaging Ctr, Montreal Neurol Inst, Neuroimaging Epilepsy Lab, Montreal, PQ H3A 2B4, Canada;

Inst Cerveau & Moelle Epiniere, Frontlab, CNRS UMR 7225, F-75013 Paris, FranceUniv York, York Neuroimaging Ctr, York YO10 5NY, N Yorkshire, England;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
hippocampus; connnectome; microstructure; MRI; neuroimaging;

Anatomical and microstructural determinants of hippocampal subfield functional connectome embedding

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