HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

Horwitz J.A.; Halper-Stromberg A.; Mouquet H.Gitlin A.D.Tretiakova A.Eisenreich T.R.Malbec M.Gravemann S.Billerbeck E.Dorner M.Büning H.Schwartz O.Knops E.Kaiser R.Seaman M.S.Wilson J.M.Rice C.M.Ploss A.Bjorkman P.J.Klein F.Nussenzweig M.C.

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HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

机译：HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

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Effective control of HIV-1 infection in humans is achieved using combinations of antiretroviral therapy (ART) drugs. In humanized mice (hu-mice), control of viremia can be achieved using either ART or by immunotherapy using combinations of broadly neutralizing antibodies (bNAbs). Here we show that treatment of HIV-1- infected hu-mice with a combination of three highly potent bNAbs not only resulted in complete viremic control but also led to a reduction in cell-associated HIV-1 DNA. Moreover, lowering the initial viral load by coadministration of ART and immunotherapy enabled prolonged viremic control by a single bNAb after ART was withdrawn. Similarly, a single injection of adeno-associated virus directing expression of one bNAb produced durable viremic control after ART was terminated. We conclude that immunotherapy reduces plasma viral load and cell-associated HIV-1 DNA and that decreasing the initial viral load enables single bNAbs to control viremia in hu-mice.

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《Proceedings of the National Academy of Sciences of the United States of America.》 |2013年第41期|16538-16543|共6页
作者
Horwitz J.A.; Halper-Stromberg A.; Mouquet H.Gitlin A.D.Tretiakova A.Eisenreich T.R.Malbec M.Gravemann S.Billerbeck E.Dorner M.Büning H.Schwartz O.Knops E.Kaiser R.Seaman M.S.Wilson J.M.Rice C.M.Ploss A.Bjorkman P.J.Klein F.Nussenzweig M.C.;
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作者单位

Laboratory of Molecular Immunology, United States;

Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States;

Department of Virology, Virus and Immunity Unit, Institut Pasteur, 75015 Paris, FranceLaboratory of Virology and Infectious Diseases, United StatesDivision of Biology, United StatesBeth Israel Deaconess Medical Center, Boston, MA 02215, United StatesDepartment of Molecular Biology, Princeton University, Princeton, NJ 08544, United States;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
CD4bs; Glycan; Gp160;

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice

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