Cyclin D2 is a GATA4 cofactor in cardiogenesis

Abir Yamak; Branko V. Latinki?; Rola DaliRana TemsahMona Nemer

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Cyclin D2 is a GATA4 cofactor in cardiogenesis

【24h】

Cyclin D2 is a GATA4 cofactor in cardiogenesis

机译：Cyclin D2 is a GATA4 cofactor in cardiogenesis

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

The G1 cyclins play a pivotal role in regulation of cell differentiation and proliferation. The mechanisms underlying their cellspecific roles are incompletely understood. Here, we show that a G1 cyclin, cyclin D2 (CycD2), enhances the activity of transcription factor GATA4, a key regulator of cardiomyocyte growth and differentiation. GATA4 recruits CycD2 to its target promoters, and their interaction results in synergistic activation of GATA-dependent transcription. This effect is specific to CycD2 because CycD1 is unable to potentiate activity of GATA4 and is CDK-independent. GATA4 physically interacts with CycD2 through a discreet N-terminal activation domain that is essential for the cardiogenic activity of GATA4. Human mutations in this domain that are linked to congenital heart disease interfere with CycD2-GATA4 synergy. Cardiogenesis assays in Xenopus embryos indicate that CycD2 enhances the cardiogenic function of GATA4. Together, our data uncover a role for CycD2 as a cardiogenic coactivator of GATA4 and suggest a paradigm for cell-specific effects of cyclin Ds.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第4期|1415-1420|共6页
作者
Abir Yamak; Branko V. Latinki?; Rola DaliRana TemsahMona Nemer;
展开▼
作者单位

Laboratory of Cardiac Development and Differentiation, Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, ON, Canada, K1N 6N5;

School of Biosciences, Cardiff University, Cardiff CF103AS, Wales, United Kingdom;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
GATA transcription factors; heart development; heart repair;

Cyclin D2 is a GATA4 cofactor in cardiogenesis

摘要

著录项

相关主题

期刊订阅