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首页> 外文期刊>International journal of clinical rheumatology. >Lumbar degenerative disc disease: All in the genes?
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Lumbar degenerative disc disease: All in the genes?

机译：腰椎间盘退变疾病：所有基因？

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摘要

Lumbar degenerative disc disease is a common ailment that causes patients significant pain, disability and psychologic distress, in addition to its large socioeconomic impact on society. The etiology of disc degeneration has been extensively studied, but our understanding remains incomplete. Increased age and male gender are risk factors for radiographic and histologic changes associated with disc degeneration. Smoking and mechanical stress have also been evaluated as causative agents, but their impact on disease development has proven to be very small. The largest influence on degeneration has been shown to come from an inherited element. Twin studies, case-control studies and large population-based studies have confirmed that a familial predisposition exists. However, the underlying genetic cause of this heritable risk remains unknown. Variations in collagens and other extracellular matrix components likely play a role, but we remain in the infancy of our understanding of this complex genetic process.
机译：腰椎间盘退变疾病是一种常见疾病，除了会给社会带来巨大的社会经济影响外，还会导致患者严重的疼痛，残疾和心理困扰。椎间盘退变的病因已被广泛研究，但我们的理解仍然不完整。年龄增加和男性性别是与椎间盘退变相关的放射学和组织学改变的危险因素。吸烟和机械压力也被认为是病因，但是事实证明它们对疾病发展的影响很小。已显示出对变性的最大影响来自遗传元素。孪生研究，病例对照研究和大量基于人口的研究已证实存在家族性倾向。但是，这种遗传风险的潜在遗传原因仍然未知。胶原蛋白和其他细胞外基质成分的变化可能起一定作用，但我们仍处于对这一复杂遗传过程的了解的初期。

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