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首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection
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Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection

机译：Type I interferon suppresses de novo virus-specific CD4 Th1 immunity during an established persistent viral infection

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摘要

CD4 T cells are central to orchestrate, sustain, and potentially regenerate antiviral immunity throughout persistent viral infections. Although the evolving immune environment during persistent infection reshapes established CD4 T-cell responses, the fate of na?ve CD4 T cells primed in the midst of persistent infection is unclear. We demonstrate that, in marked contrast to the onset of infection, virus-specific CD4 T cells primed during an established persistent infection have diminished ability to develop Th1 responses, to efficiently accumulate in peripheral tissues, and almost exclusively differentiate into T follicular helper cells. Consistent with suppressed Th1 and heightened Tfh differentiation, virusspecific CD4 T cells primed during the established persistent infection provide help to B cells, but only limited help to CD8 T cells. The suppression of de novo Th1 generation and tissue distribution was mediated by chronic type I IFN (IFN-I) production and was effectively restored by blocking IFN-I signaling during CD4 T-cell priming. Thus, we establish a suppressive function of chronic IFN-I signaling and mechanism of immunoregulation during an established persistent virus infection.

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