The Cancer Genome Atlas and other largescale cancer genome sequencing projects have identified an impressive number of significantly mutated genes that are likely drivers of cancer progression (1). These studies have definitively confirmed that the gene encoding the p53 tumor suppressor is the most frequently mutated gene in human cancers. A major component of the p53 anticancer response is its ability to arrest cell division at different stages of the cell cycle. In PNAS, a study by Shaltiel et al. provides additional insights into the mechanisms of reversal of the p53-mediated cell cycle arrest (2). Such insights may provide new cancer therapeutic opportunities.
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Departments of Molecular Virology and Microbiology, Molecular, and Cellular Biology, Pediatrics and the Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030;
