Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells

Yukiko Watanabe; Atsushi Onodera; Urara KanaiTomomi IchikawaKazushige Obata-NinomiyaTomoko WadaMasahiro KiuchiChiaki IwamuraDamon J. TumesKenta ShinodaRyoji YagiShinichiro MotohashiKiyoshi HiraharaToshinori Nakayama

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells

【24h】

Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells

机译：Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Epigenetic modifications, such as posttranslational modifications of histones, play an important role in gene expression and regulation. These modifications are in part mediated by the Trithorax group (TrxG) complex and the Polycomb group (PcG) complex, which activate and repress transcription, respectively. We herein investigate the role of Menin, a component of the TrxG complex in T helper (Th) cell differentiation and show a critical role for Menin in differentiation and maintenance of Th17 cells. Menin~(-/-) T cells do not efficiently differentiate into Th17 cells, leaving Th1 and Th2 cell differentiation intact in in vitro cultures. Menin deficiency resulted in the attenuation of Th17-induced airway inflammation. In differentiating Th17 cells, Menin directly bound to the Il17a gene locus and was required for the deposition of permissive histone modifications and recruitment of the RNA polymerase II transcriptional complex. Interestingly, although Menin bound to the Rorc locus, Menin was dispensable for the induction of Rorc expression and permissive histone modifications in differentiating Th17 cells. In contrast, Menin was required to maintain expression of Rorc in differentiated Th17 cells, indicating that Menin is essential to stabilize expression of the Rorc gene. Thus, Menin orchestrates Th17 cell differentiation and function by regulating both the induction and maintenance of target gene expression.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第35期|12829-12834|共6页
作者
Yukiko Watanabe; Atsushi Onodera; Urara KanaiTomomi IchikawaKazushige Obata-NinomiyaTomoko WadaMasahiro KiuchiChiaki IwamuraDamon J. TumesKenta ShinodaRyoji YagiShinichiro MotohashiKiyoshi HiraharaToshinori Nakayama;
展开▼
作者单位

Departments of Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan;

Departments of Medical Immunology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan;

Departments of Advanced Allergology of the Airway, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Menin controls; differentiation; maintenance;

Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells

摘要

著录项

相关主题

期刊订阅