Human and Helicobacter pylori coevolution shapes the risk of gastric disease

Nuri Kodaman; Alvaro Pazos; Barbara G. SchneiderM. Blanca PiazueloRobertino MeraRafal S. SobotaLiviu A. SicinschiCarrie L. ShafferJudith Romero-GalloThibaut de SabletReed H. HarderLuis E. BravoRichard M. Peek Jr.Keith T. WilsonTimothy L. CoverScott M. WilliamsPelayo Correa

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Human and Helicobacter pylori coevolution shapes the risk of gastric disease

机译：Human and Helicobacter pylori coevolution shapes the risk of gastric disease

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Helicobacter pylori is the principal cause of gastric cancer, the second leading cause of cancer mortality worldwide. However, H. pylori prevalence generally does not predict cancer incidence. To determine whether coevolution between host and pathogen influences disease risk, we examined the association between the severity of gastric lesions and patterns of genomic variation in matched human and H. pylori samples. Patients were recruited from two geographically distinct Colombian populations with significantly different incidences of gastric cancer, but virtually identical prevalence of H. pylori infection. All H. pylori isolates contained the genetic signatures of multiple ancestries, with an ancestral African cluster predominating in a low-risk, coastal population and a European cluster in a high-risk, mountain population. The human ancestry of the biopsied individuals also varied with geography, with mostly African ancestry in the coastal region (58), and mostly Amerindian ancestry in the mountain region (67). The interaction between the host and pathogen ancestries completely accounted for the difference in the severity of gastric lesions in the two regions of Colombia. In particular, African H. pylori ancestry was relatively benign in humans of African ancestry but was deleterious in individuals with substantial Amerindian ancestry. Thus, coevolution likely modulated disease risk, and the disruption of coevolved human and H. pylori genomes can explain the high incidence of gastric disease in the mountain population.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第4期|1455-1460|共6页
作者
Nuri Kodaman; Alvaro Pazos; Barbara G. SchneiderM. Blanca PiazueloRobertino MeraRafal S. SobotaLiviu A. SicinschiCarrie L. ShafferJudith Romero-GalloThibaut de SabletReed H. HarderLuis E. BravoRichard M. Peek Jr.Keith T. WilsonTimothy L. CoverScott M. WilliamsPelayo Correa;
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作者单位

Department of Biology, University of Nari?o, Pasto, Colombia 520002;

Divisions of Gastroenterology, Vanderbilt University Medical Center, Nashville, TN 37232;

Center for Human Genetics Research, Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center, Nashville, TN 37232Department of Microbiology and Immunology, Holmes Regional Medical Center, Melbourne, FL 32901Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232Department of Genetics, Geisel School of Medicine, Dartmouth College, Hanover, NH 03755Department of Pathology, School of Medicine, Universidad del Valle, Cali, Colombia 760043;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
admixture; histopathology; inflammation; Latin America;

Human and Helicobacter pylori coevolution shapes the risk of gastric disease

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