Near-infrared-actuated devices for remotely controlled drug delivery

Brian P. Timko; Manuel Arruebo; Sahadev A. ShankarappaJ. Brian McAlvinObiajulu S. OkonkwoBoaz MizrahiCristina F. StefanescuLeyre GomezJia ZhuAngela ZhuJesus SantamariaRobert LangerDaniel S. Kohane

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Near-infrared-actuated devices for remotely controlled drug delivery

机译：Near-infrared-actuated devices for remotely controlled drug delivery

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A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage to desired effect, with a consequent minimization of toxicity, and could obviate repeated drug administrations or device implantations, enhancing patient compliance. It should exhibit low off-state leakage to minimize basal effects, and tunable on-state release profiles that could be adjusted from pulsatile to sustained in real time. Despite the clear clinical need for a device that meets these criteria, none has been reported to date to our knowledge. To address this deficiency, we developed an implantable reservoir capped by a nanocomposite membrane whose permeability was modulated by irradiation with a near-infrared laser. Irradiated devices could exhibit sustained onstate drug release for at least 3 h, and could reproducibly deliver short pulses over at least 10 cycles, with an on/off ratio of 30. Devices containing aspart, a fast-acting insulin analog, could achieve glycemic control after s.c. implantation in diabetic rats, with reproducible dosing controlled by the intensity and timing of irradiation over a 2-wk period. These devices can be loaded with a wide range of drug types, and therefore represent a platform technology that might be used to address a wide variety of clinical indications.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第4期|1349-1354|共6页
作者
Brian P. Timko; Manuel Arruebo; Sahadev A. ShankarappaJ. Brian McAlvinObiajulu S. OkonkwoBoaz MizrahiCristina F. StefanescuLeyre GomezJia ZhuAngela ZhuJesus SantamariaRobert LangerDaniel S. Kohane;
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作者单位

Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115;

Networking Research Center in Bioengineering, Biomaterials and Nanomedicine, E-50018 Zaragoza, Spain;

Center for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Center, Kochi 682 041, IndiaInstitute of Nanoscience of Aragón and Department of Chemical Engineering, University of Zaragoza, E-50018 Zaragoza, SpainKoch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA 02139Department of Chemistry and Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
gold; nanoshell; poly(n-isopropylacrylamide); ethylcellulose; diabetes;

Near-infrared-actuated devices for remotely controlled drug delivery

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