Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells

Dirk Brenner; Anne Brüstle; Gloria H. Y. LinPhilipp A. LangGordon S. DuncanChristiane B. Knobbe-ThomsenMichael St. PaulColin ReardonMichael W. TuscheBryan SnowSara R. HamiltonAline PfefferleSyed O. GilaniPamela S. OhashiKarl S. LangTak W. Mak

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells

【24h】

Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells

机译：Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

The ability to mount a strong immune response against pathogens is crucial for mammalian survival. However, excessive and uncontrolled immune reactions can lead to autoimmunity. Unraveling how the reactive versus tolerogenic state is controlled might point toward novel therapeutic strategies to treat autoimmune diseases. The surface receptor Toso/Faim3 has been linked to apoptosis, IgM binding, and innate immune responses. In this study, we used Toso-deficient mice to investigate the importance of Toso in tolerance and autoimmunity. We found that Toso~(-/-) mice do not develop severe experimental autoimmune encephalomyelitis (EAE), a mouse model for the human disease multiple sclerosis. Toso~(-/-) dendritic cells were less sensitive to Toll-like receptor stimulation and induced significantly lower levels of disease-associated inflammatory T-cell responses. Consistent with this observation, the transfer of Toso~(-/-) dendritic cells did not induce autoimmune diabetes, indicating their tolerogenic potential. In Toso~(-/-) mice subjected to EAE induction, we found increased numbers of regulatory T cells and decreased encephalitogenic cellular infiltrates in the brain. Finally, inhibition of Toso activity in vivo at either an early or late stage of EAE induction prevented further disease progression. Taken together, our data identify Toso as a unique regulator of inflammatory autoimmune responses and an attractive target for therapeutic intervention.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2014年第3期|1060-1065|共6页
作者
Dirk Brenner; Anne Brüstle; Gloria H. Y. LinPhilipp A. LangGordon S. DuncanChristiane B. Knobbe-ThomsenMichael St. PaulColin ReardonMichael W. TuscheBryan SnowSara R. HamiltonAline PfefferleSyed O. GilaniPamela S. OhashiKarl S. LangTak W. Mak;
展开▼
作者单位

The Campbell Family Cancer Research Institute, Ontario Cancer Institute, University Health Network, Toronto, ON, Canada M5G 2C1;

Institute of Immunology, University Hospital, University Duisburg-Essen, 45147 Essen, Germany;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
inflammation; Th1/Th17 cells;

Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells

摘要

著录项

相关主题

期刊订阅