Delay discounting, genetic sensitivity, and leukocyte telomere length

Yim Onn-Siong; Zhang Xing; Shalev IdanMonakhov MikhailZhong SongfaHsu MingChew Soo HongLai Poh SanEbstein Richard P.

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Delay discounting, genetic sensitivity, and leukocyte telomere length

机译：Delay discounting, genetic sensitivity, and leukocyte telomere length

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In a graying world, there is an increasing interest in correlates of aging, especially those found in early life. Leukocyte telomere length (LTL) is an emerging marker of aging at the cellular level, but little is known regarding its link with poor decision making that often entails being overly impatient. Here we investigate the relationship between LTL and the degree of impatience, which is measured in the laboratory using an incentivized delay discounting task. In a sample of 1,158 Han Chinese undergraduates, we observe that steeper delay discounting, indexing higher degree of impatience, is negatively associated with LTL. The relationship is robust after controlling for health-related variables, as well as risk attitude-another important determinant of decision making. LTL in females is more sensitive to impatience than in males. We then asked if genes possibly modulate the effect of impatient behavior on LTL. The oxytocin receptor gene (OXTR) polymorphism rs53576, which has figured prominently in investigations of social cognition and psychological resources, and the estrogen receptor beta gene (ESR2) polymorphism rs2978381, one of two gonadal sex hormone genes, significantly mitigate the negative effect of impatience on cellular aging in females. The current results contribute to understanding the relationship between preferences in decision making, particularly impatience, and cellular aging, for the first time to our knowledge. Notably, oxytocin and estrogen receptor polymorphisms temper accelerated cellular aging in young females who tend to make impatient choices.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2016年第10期|2780-2785|共6页
作者
Yim Onn-Siong; Zhang Xing; Shalev IdanMonakhov MikhailZhong SongfaHsu MingChew Soo HongLai Poh SanEbstein Richard P.;
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作者单位

Natl Univ Singapore, Dept Psychol, Singapore 117570, Singapore;

Swiss Fed Inst Technol Zurich, Singapore ETH Ctr Global Environm Sustainabil, Singapore 138602, Singapore;

Penn State Univ, Dept Biobehav Hlth, University Pk, PA 16802 USANatl Univ Singapore, Dept Econ, Singapore 117570, SingaporeUniv Calif Berkeley, Haas Sch Business, Berkeley, CA 94720 USANatl Univ Singapore, Dept Paediat, Human Genet Lab, Singapore 119228, Singapore;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
telomere length; delay discounting; risk attitude; oxytocin receptor; estrogen receptor;

Delay discounting, genetic sensitivity, and leukocyte telomere length

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