Combining multiple optical trapping with microflow manipulation for the rapid bioanalytics on microparticles in a chip

Boer  G; Johann  R; Rohner  JMerenda  FDelacretaz  GRenaud  PSalathe  RP

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Combining multiple optical trapping with microflow manipulation for the rapid bioanalytics on microparticles in a chip

机译：Combining multiple optical trapping with microflow manipulation for the rapid bioanalytics on microparticles in a chip

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An array of four independent laser traps is combined with a polydimethylsiloxane microfluidic chip to form a very compact system allowing parallel processing of biological objects. Strong three dimensional trapping allows holding objects such as functionalized beads in flows at speeds near 1 mm/s, enabling rapid processing. By pressure control of the inlet flows, the trapped objects can be put in contact with different solutions for analysis purpose. This setup, including a fluorescence excitation-detection scheme, offers the potential to perform complex biochemical manipulations on an ensemble of microparticles. (c) 2007 American Institute of Physics.

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《Review of Scientific Instruments》 |2007年第11期|116101-1-116101-3-0|共3页
作者
Boer G; Johann R; Rohner JMerenda FDelacretaz GRenaud PSalathe RP;
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作者单位

IBMT, Fraunhofer Inst Biomed Tech, D-66386 St Ingbert, Germany;

ARCoptix S A, NE-2000 Neuchatel, Switzerland;

Ecole Polytech Fed Lausanne, EPFL, Lab Photon Appliquee, CH-1015 Lausanne, SwitzerlandEcole Polytech Fed Lausanne, EPFL, Lab Microsyst 4, CH-1015 Lausanne, Switzerland;

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正文语种英语
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TWEEZERS; SYSTEMS; DEVICES; FORCES; CELLS;

Combining multiple optical trapping with microflow manipulation for the rapid bioanalytics on microparticles in a chip

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