Synthesis and antimicrobial evaluation of new pyrano4,3-bpyran and pyrano3,2-cchromene derivatives bearing a 2-thiophenoxyquinoline nucleus

MakawanaJ.A.; PatelM.P.; PatelR.G.

首页> 外文期刊>Archiv der Pharmazie >Synthesis and antimicrobial evaluation of new pyrano4,3-bpyran and pyrano3,2-cchromene derivatives bearing a 2-thiophenoxyquinoline nucleus

【24h】

Synthesis and antimicrobial evaluation of new pyrano4,3-bpyran and pyrano3,2-cchromene derivatives bearing a 2-thiophenoxyquinoline nucleus

机译：带有2-噻吩氧基喹啉核的新型吡喃并4,3-b吡喃和吡喃并3,2-c色烯衍生物的合成和抗菌评价

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

A new series of pyrano4,3-bpyran 4a-i and pyrano3,2-cchromene 6a-r derivatives bearing a 2-thiophenoxyquinoline nucleus were synthesized by reaction of 2-(4-(un)-substituted thiophenoxy)quinoline-3-carbaldehydes 2a-i with 6-methyl-4-hydroxypyran-2-one 3 and 4-hydroxy-6-(un)-substituted-2H- chromen-2-one 5a-b respectively and malononitrile at room temperature in the presence of KOH as a basic catalyst. All the compounds were screened against three Gram-positive bacteria (Streptococcus pneumoniae, Bacillus subtilis, Clostridium tetani), three Gram-negative bacteria (Salmonella typhi, Escherichia coli, Vibrio cholerae) and two fungi (Candida albicans, Aspergillus fumigatus) using the broth microdilution MIC (minimum inhibitory concentration) method. Upon antimicrobial screening, it was observed that the majority of the compounds were found to be active against Bacillus subtilis, Clostridium tetani and Candida albicans as compared to standard drugs. A new series of pyrano4,3-bpyran 4a-i and pyrano3,2-cchromene 6a-r derivatives bearing a 2-thiophenoxyquinoline nucleus were synthesized. All compounds were screened against three Gram-positive bacteria, three Gram-negative bacteria and two fungi. The majority of the compounds were found to be active against Bacillus subtilis, Clostridium tetani and Candida albicans as compared to standard drugs.

机译：以KOH为碱性催化剂，以2-（4-（un）-取代噻吩氧基）喹啉-3-甲醛2a-i与6-甲基-4-羟基吡喃-2-酮3和4-羟基-6-（un）-取代-2H-苯并吡喃-2-酮5a-b和丙二腈反应，合成了带有2-噻吩氧基喹啉核的吡喃并[4,3-b]吡喃4a-i和吡喃[3,2-c]色烯-2-酮5a-r衍生物。采用肉汤微量稀释MIC（最小抑制浓度）法对3种革兰氏阳性菌（肺炎链球菌、枯草芽孢杆菌、破伤风梭菌）、3种革兰氏阴性菌（伤寒沙门氏菌、大肠杆菌、霍乱弧菌）和2种真菌（白色念珠菌、烟曲霉）进行筛选。经抗菌药物筛选，发现与标准药物相比，大多数化合物对枯草芽孢杆菌、破伤风梭菌和白色念珠菌具有活性。合成了带有2-噻吩氧基喹啉核的新型吡喃并[4,3-b]吡喃4a-i和吡喃并[3,2-c]色烯6a-r衍生物。对3种革兰氏阳性菌、3种革兰氏阴性菌和2种真菌进行筛选。与标准药物相比，大多数化合物被发现对枯草芽孢杆菌、破伤风梭菌和白色念珠菌具有活性。

著录项

来源
《Archiv der Pharmazie》 |2012年第4期|314-322|共9页
作者
MakawanaJ.A.; PatelM.P.; PatelR.G.;
展开▼
作者单位

Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388120, Gujarat, India;

展开▼
收录信息
原文格式 PDF
正文语种德语
中图分类药学;
关键词
2-Thiophenoxyquinoline; Chromene; In vitro antimicrobial activity; Pyran;

机译：2-噻吩氧基喹啉;铬;体外抗菌活性;皮兰;

相似文献

外文文献
中文文献
专利

1. ChemInform Abstract: The Synthesis and Transformations of 2H‐Naphtho(1,2‐b)pyran‐2‐one Derivatives. Naphtho(2′,1′:5,6)pyrano(3,4‐d)(1,3)oxazines and Naphtho( 1′,2′:5,6)pyrano(3,4‐d)pyrimidines, Derivatives of Two New Heterocyclic Systems. [J] . S. FAJGELJ, B. STANOVNIK, M. TISLER Chem Inform . 1991,第19期

机译：ChemInform Abstract: The Synthesis and Transformations of 2H‐Naphtho(1,2‐b)pyran‐2‐one Derivatives. Naphtho(2′,1′:5,6)pyrano(3,4‐d)(1,3)oxazines and Naphtho( 1′,2′:5,6)pyrano(3,4‐d)pyrimidines, Derivatives of Two New Heterocyclic Systems.
2. Studies on Substituted Heteroarenes: New Synthesis of Substituted Pyrrole, Pyridine, Pyrazolo4,3-bpyridine, Pyrano 3,2-cquinoline, Benzo f chromene, Benzoh chromene, Chromeno 8,7-hchromene, Chromeno6,5-f chromene and 2H-chromene Derivatives [J] . F. M. A. El-Taweel, A. A. Elagamey, Sh. M. Elmougy Egyptian Journal of Chemistry . 2012,第5期

机译：Studies on Substituted Heteroarenes: New Synthesis of Substituted Pyrrole, Pyridine, Pyrazolo4,3-bpyridine, Pyrano 3,2-cquinoline, Benzo f chromene, Benzoh chromene, Chromeno 8,7-hchromene, Chromeno6,5-f chromene and 2H-chromene Derivatives
3. In vitro antimicrobial evaluation and in silico studies of coumarin derivatives tagged with pyrano-pyridine and pyrano-pyrimidine moieties as DNA gyrase inhibitors [J] . Fayed Eman A., Nosseir Eman S., Atef AhmedEl‑Kalyoubi Samar A. Molecular diversity . 2022,第1期

机译：In vitro antimicrobial evaluation and in silico studies of coumarin derivatives tagged with pyrano-pyridine and pyrano-pyrimidine moieties as DNA gyrase inhibitors
4. The Niementowski reaction of anthranilic acid with ethyl acetoacetate revisited: a new access to pyrano[3,2-c]quinoline-2,5-dione [O] . Yevgen M Poronik, Jan Klajn, Wioleta Borzęcka, 2016

机译：重新考虑邻氨基苯甲酸与乙酰乙酸乙酯的Niementowski反应：新的pyrano [3,2-c]喹啉-2,5-二酮

Synthesis and antimicrobial evaluation of new pyrano4,3-bpyran and pyrano3,2-cchromene derivatives bearing a 2-thiophenoxyquinoline nucleus

摘要

著录项

相似文献

相关主题

期刊订阅