Circadian acetylome reveals regulation of mitochondrial metabolic pathways

Masri S.; Patel V.R.; Eckel-Mahan K.L.Peleg S.Forne I.Ladurner A.G.Baldi P.Imhof A.Sassone-Corsi P.

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Circadian acetylome reveals regulation of mitochondrial metabolic pathways

机译：Circadian acetylome reveals regulation of mitochondrial metabolic pathways

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The circadian clock is constituted by a complex molecular network that integrates a number of regulatory cues needed to maintain organismal homeostasis. To this effect, posttranslational modifications of clock proteins modulate circadian rhythms and are thought to convert physiological signals into changes in protein regulatory function. To explore reversible lysine acetylation that is dependent on the clock, we have characterized the circadian acetylome in WT and Clock-deficient (Clock~(-/-)) mouse liver by quantitative mass spectrometry. Our analysis revealed that a number of mitochondrial proteins involved in metabolic pathways are heavily influenced by clock-driven acetylation. Pathways such as glycolysis/gluconeogenesis, citric acid cycle, amino acid metabolism, and fatty acid metabolism were found to be highly enriched hits. The significant number of metabolic pathways whose protein acetylation profile is altered in Clock~(-/-) mice prompted us to link the acetylome to the circadian metabolome previously characterized in our laboratory. Changes in enzyme acetylation over the circadian cycle and the link to metabolite levels are discussed, revealing biological implications connecting the circadian clock to cellular metabolic state.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第9期|3339-3344|共6页
作者
Masri S.; Patel V.R.; Eckel-Mahan K.L.Peleg S.Forne I.Ladurner A.G.Baldi P.Imhof A.Sassone-Corsi P.;
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作者单位

Center for Epigenetics and Metabolism, University of California, Irvine, CA 92697, United States;

Institute for Genomics and Bioinformatics, University of California, Irvine, CA 92697, United States;

Munich Center of Integrated Protein Science, Adolf-Butenandt Institute, Ludwig Maximilians University of Munich, 80336 Munich, Germany;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Chromatin; Epigenetics;

Circadian acetylome reveals regulation of mitochondrial metabolic pathways

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