The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki-Miyaura cross-coupling reaction.

Huang J; Orac CM; McKay SMcKay DBBergmeier SC

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The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki-Miyaura cross-coupling reaction.

机译：The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki-Miyaura cross-coupling reaction.

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摘要

Novel 3,5-disubstituted ring E analogs of methyllycaconitine were prepared and evaluated in nicotinic acetylcholine receptor binding assays. The desired analogs were prepared through the Suzuki-Miyaura cross-coupling reaction of methyl 5-bromo-nicotinate. The Suzuki-Miyaura cross-coupling reactions of pyridines with electron withdrawing substituents have not been extensively described previously.

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来源
《Bioorganic and medicinal chemistry》 |2008年第7期|3816-3824|共9页
作者
Huang J; Orac CM; McKay SMcKay DBBergmeier SC;
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作者单位

Department of Chemistry and Biochemistry, Ohio University, Clippinger Laboratories, Athens, OH 45701, USA.;

ost.saga-med.ac.jp;

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原文格式 PDF
正文语种英语
中图分类药学;生物化学;
关键词
Aconitine; Cross-Linking Reagents; Hydrogenation; Molecular Structure; Protein Binding; 乌头碱; 交联试剂; 氢化作用; 分子结构; 蛋白质结合; 受体; 胆碱能; 立体异构现象;

The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki-Miyaura cross-coupling reaction.

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