Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis

Chandriani S.; Skewes-Cox P.; Zhong W.Ganem D.E.Divers T.J.Van Blaricum A.J.Tennant B.C.Kistler A.L.

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Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis

机译：Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis

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Theiler' s disease is an acute hepatitis in horses that is associated with the administration of equine blood products; its etiologic agent has remained unknown for nearly a century. Here, we used massively parallel sequencing to explore samples from a recent Theiler' s disease outbreak. Metatranscriptomic analysis of the short sequence reads identified a 10.5-kb sequence from a previously undescribed virus of the Flaviviridae family, which we designate "Theiler' s disease-associated virus" (TDAV). Phylogenetic analysis clusters TDAV with GB viruses of the recently proposed Pegivirus genus, although it shares only 35.3 amino acid identity with its closest relative, GB virus D. An epidemiological survey of additional horses from three separate locations supports an association between TDAV infection and acute serum hepatitis. Experimental inoculation of horses with TDAV-positive plasma provides evidence that several weeks of viremia preceded liver injury and that liver disease may not be directly related to the level of viremia. Like hepatitis C virus, the best characterized Flaviviridae species known to cause hepatitis, we find TDAV is capable of efficient parenteral transmission, engendering acute and chronic infections associated with a diversity of clinical presentations ranging from subclinical infection to clinical hepatitis.

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《Proceedings of the National Academy of Sciences of the United States of America》 |2013年第15期|5752-5753|共2页
作者
Chandriani S.; Skewes-Cox P.; Zhong W.Ganem D.E.Divers T.J.Van Blaricum A.J.Tennant B.C.Kistler A.L.;
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作者单位

Department of Infectious Diseases, Novartis Institutes for BioMedical Research, Emeryville, CA 94608, United States;

Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, United States;

Las Vegas, NV 89131;

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收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Deep sequencing; Epidemiology; Metagenomics; Pathogen discovery; Veterinary virology;

Identification of a previously undescribed divergent virus from the Flaviviridae family in an outbreak of equine serum hepatitis

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