Biased gene transfer mimics patterns created through shared ancestry

Andam C.P.; Williams D.; Gogarten J.P.

首页> 外文期刊>Proceedings of the National Academy of Sciences of the United States of America >Biased gene transfer mimics patterns created through shared ancestry

【24h】

Biased gene transfer mimics patterns created through shared ancestry

机译：Biased gene transfer mimics patterns created through shared ancestry

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

In phylogenetic reconstruction, two types of bacterial tyrosyl-tRNA synthetases (TyrRS) form distinct clades with many bacterial phyla represented in both clades. Very few taxa possess both forms, and maximum likelihood analysis of the distribution of TyrRS types suggests horizontal gene transfer (HGT), rather than an ancient duplication followed by differential gene loss, as the contributor to the evolutionary history of TyrRS in bacteria. However, for each TyrRS type, phylogenetic reconstruction yields phylogenies similar to the ribosomal phylogeny, revealing that frequent gene transfer has not destroyed the expected phylogeny; rather, the expected phylogenetic signal was reinforced or even created by HGT. We show that biased HGT can mimic patterns created through shared ancestry by in silico simulation. Furthermore, in cases where genomic synteny is sufficient to allow comparisons of relative gene positions, both tyrRS types occupy equivalent positions in closely related genomes, rejecting the loss hypothesis. Although the two types of bacterial TyrRS are only distantly related and only rarely coexist in a single genome, they have many features in common with alleles that are swapped between related lineages. We propose to label these functionally similar homologs as homeoalleles. We conclude that the observed phylogenetic pattern reflects both vertical inheritance and biased HGT and that the signal caused by common organismal descent is difficult to distinguish from the signal due to biased gene transfer.

著录项

来源
《Proceedings of the National Academy of Sciences of the United States of America》 |2010年第23期|10679-10684|共6页
作者
Andam C.P.; Williams D.; Gogarten J.P.;
展开▼
作者单位

Department of Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269-3125, United States;

展开▼
收录信息美国《科学引文索引》(SCI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类自然科学总论;
关键词
Aminoacyl; Bacteria; Evolution; Horizontal gene transfer; Lateral gene transfer; tRNA synthetase;

Biased gene transfer mimics patterns created through shared ancestry

摘要

著录项

相关主题

期刊订阅