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首页> 外文期刊>The Journal of Clinical Investigation: The Official Journal of the American Society for Clinical Investigation >Chikungunya infection: de-linking replication from symptomatology reveals the central role of muscle COMMENT
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Chikungunya infection: de-linking replication from symptomatology reveals the central role of muscle COMMENT

机译：基孔肯雅热感染：将复制与症状脱钩揭示了肌肉的核心作用 评论

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摘要

Chikungunya virus (CHIKV) is an emerging arbovirus, endemic in many parts of the world, that is spread by travelers and adapts to new mosquito vectors that live in temperate climates. CHIKV replicates in many host tissues and initially causes a self-limiting febrile illness similar to dengue. However, in 30-40 of cases, CHIKV also causes long-term painful and debilitating muscle and joint pain, the pathogenesis of which remains unknown. In this issue of the JCI, Lentscher et al. engineered a skeletal muscle-restricted CHIKV to show that while musculoskeletal disease requires viral replication in affected muscle, muscular pathology is mediated by host immunological factors. These findings de-link viral replication and disease symptoms, illuminate the virus-host interplay in CHIKV symptomatology, and raise the possibility that immune modulation is a therapeutic option. The results also highlight possible solutions to existing vaccine barriers and provide insights that may apply to other viral diseases.
机译：基孔肯雅病毒（CHIKV）是一种新兴的虫媒病毒，在世界许多地方流行，由旅行者传播，并适应生活在温带气候中的新蚊媒。CHIKV在许多宿主组织中复制，最初引起类似于登革热的自限性发热性疾病。然而，在30%-40%的病例中，CHIKV也会引起长期疼痛和衰弱的肌肉和关节疼痛，其发病机制仍然未知。在本期 JCI 中，Lentscher 等人设计了一种骨骼肌限制性 CHIKV，以表明虽然肌肉骨骼疾病需要病毒在受影响的肌肉中复制，但肌肉病理学是由宿主免疫因子介导的。这些发现将病毒复制与疾病症状脱钩，阐明了 CHIKV 症状学中的病毒-宿主相互作用，并提出了免疫调节是一种治疗选择的可能性。研究结果还强调了现有疫苗障碍的可能解决方案，并提供了可能适用于其他病毒性疾病的见解。

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