Oral N-acetylcysteine improves cone function in retinitis pigmentosa patients in phase I trial

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Oral N-acetylcysteine improves cone function in retinitis pigmentosa patients in phase I trial

机译：口服 N-乙酰半胱氨酸在 I 期试验中改善视网膜色素变性患者的视锥细胞功能

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BACKGROUND. In retinitis pigmentosa (RP), rod photoreceptors degenerate from 1 of many mutations, after which cones are compromised by oxidative stress. N-acetylcysteine (NAC) reduces oxidative damage and increases cone function/survival in RP models. We tested the safety, tolerability, and visual function effects of oral NAC in RP patients.

机译：背景。在视网膜色素变性（RP）中，视杆光感受器从许多突变中的一种退化，之后视锥细胞受到氧化应激的影响。N-乙酰半胱氨酸（NAC）可减少 RP 模型中的氧化损伤并增加视锥细胞功能/存活率。我们测试了口服 NAC 对 RP 患者的安全性、耐受性和视觉功能影响。

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《The Journal of Clinical Investigation: The Official Journal of the American Society for Clinical Investigation》 |2020年第3期|1527-1541|共15页
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正文语种英语
中图分类临床医学;
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Oral N-acetylcysteine improves cone function in retinitis pigmentosa patients in phase I trial

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