New insights into apoptosis signaling by Apo2L/TRAIL.

Gonzalvez F; Ashkenazi A

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New insights into apoptosis signaling by Apo2L/TRAIL.

机译：Apo2L/TRAIL对细胞凋亡信号传导的新见解。

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Apoptosis ligand 2 tumor necrosis factor (TNF)-related apoptosis-inducing ligand (Apo2L/TRAIL) belongs to a small subset of proapoptotic protein ligands in the TNF superfamily. This subset, which also includes Fas ligand and TNF-alpha, can activate the extrinsic apoptotic cell death pathway on binding to cognate death receptors at the cell surface. Over the past 10 years, Apo2L/TRAIL has emerged as a promising candidate for cancer therapy, on the basis of its unique ability to trigger apoptosis in various types of cancer cells without significant toxicity toward normal cells. Herein, we review key advances in understanding the molecular events that control apoptosis signaling by Apo2L/TRAIL, which may aid in the development of cancer therapies based on the extrinsic apoptotic pathway.

机译：细胞凋亡配体 2 肿瘤坏死因子（TNF）相关凋亡诱导配体（Apo2L/TRAIL）属于 TNF 超家族中促凋亡蛋白配体的一小部分。该亚群还包括 Fas 配体和 TNF-α，在与细胞表面的同源死亡受体结合时可以激活外源性凋亡细胞死亡途径。在过去的 10 年中，Apo2L/TRAIL 已成为癌症治疗的有前途的候选药物，因为它具有在各种类型的癌细胞中触发细胞凋亡的独特能力，而对正常细胞没有显着毒性。在此，我们回顾了理解 Apo2L/TRAIL 控制细胞凋亡信号传导的分子事件的关键进展，这可能有助于开发基于外源性凋亡途径的癌症疗法。

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《Oncogene》 |2010年第34期|4752-4765|共14页
作者
Gonzalvez F; Ashkenazi A;
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Department of Molecular Oncology, Genentech Inc., South San Francisco, CA, USA.;

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正文语种英语
中图分类肿瘤学;
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New insights into apoptosis signaling by Apo2L/TRAIL.

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