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首页> 外文期刊>International journal of molecular imaging >Beneficial Effect of Glucose Control on Atherosclerosis Progression in Diabetic ApoE~(-/-) Mice: Shown by Rage Directed Imaging
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Beneficial Effect of Glucose Control on Atherosclerosis Progression in Diabetic ApoE~(-/-) Mice: Shown by Rage Directed Imaging

机译：血糖控制对糖尿病ApoE〜（-/-）小鼠动脉粥样硬化进展的有益作用：通过愤怒定向成像显示

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Objective. Receptor for advanced glycated endproducts (RAGE) plays an important role in atherogenesis in diabetes. We imaged RAGE to investigate the effect of glucose control to suppress RAGE and reduce atherosclerosis in apolipoprotein E null (apoE~(-/-)) diabetic mice. Methods and Results. Thirty-three apoE~(-/-) mice received streptozotocin and 6 weeks later 15 began treatment with insulin implants. Blood glucose measurements during study averaged: 140 ± 23mg/dL (treated) and 354 ± 14mg/dL (untreated). After 15 wk 30 mice were injected with ~(99m)Tc-anti-RAGE F(ab')_2,3 with ~(99m)Tc-nonimmune IgG F(ab')_2, and all with CT contrast agent and underwent SPECT/CT imaging. At necropsy, the proximal aorta was weighed, counted, and sectioned and the % injected dose per gram (%ID/g) was calculated. From the merged SPECT/CT scans, tracer uptake localized to arteries was lower in the treated mice: 3.15 ± 1.82 x 10~(-3) versus 8.69 ± 4.58 x 10~(-3)%ID (P = 0.001). Percent cross-sectional lesion area was smaller in the treated (14.3 ± 7.8% versus 29.5 ± 10.9%) (P = 0.03). RAGE uptake on scans (%ID) correlated with quantitative RAGE staining in the atheroma and with %ID/g (R = 0.6887; P - 0.01). Lesion size as percent cross-sectional area was smaller in the treated (14.3 ± 7.8% versus 29.5 ± 10.9%) (P = 0.03). RAGE uptake on scans (%ID) correlated with quantitative RAGE staining in the atheroma and with %ID/g (R = 0.6887; P = 0.01). Conclusions. These results support the importance of suppressing RAGE to reduce atherosclerotic complications of diabetes and value of molecular imaging to assess treatment effect.
机译：目的。晚期糖基化终产物（RAGE）的受体在糖尿病的动脉粥样硬化中起重要作用。我们对RAGE进行了成像，以研究葡萄糖控制在抑制载脂蛋白E null（apoE〜（-/-））糖尿病小鼠中抑制RAGE和减少动脉粥样硬化的作用。方法和结果。 33只apoE〜（-/-）小鼠接受链脲佐菌素治疗，6周后15只开始用胰岛素植入物治疗。研究期间的平均血糖测量值：140±23mg / dL（治疗）和354±14mg / dL（未治疗）。 15周后，向30只小鼠注射〜（99m）Tc-抗RAGE F（ab'）_ 2,3和〜（99m）Tc-非免疫IgG F（ab'）_ 2，所有小鼠均接受CT造影剂并接受SPECT / CT成像。尸检时，称量，计数和切片近侧主动脉，并计算每克的注射剂量％（％ID / g）。从合并的SPECT / CT扫描结果来看，在治疗的小鼠中，示踪剂在动脉中的摄取较低：3.15±1.82 x 10〜（-3）％相对于8.69±4.58 x 10〜（-3）％ID（P = 0.001）。经治疗的横断面病变面积百分比较小（14.3±7.8％对29.5±10.9％）（P = 0.03）。扫描中的RAGE摄取（％ID）与动脉粥样硬化中定量RAGE染色以及％ID / g相关（R = 0.6887; P-0.01）。在治疗组中，病变面积占横截面积的百分比较小（14.3±7.8％对29.5±10.9％）（P = 0.03）。扫描中的RAGE摄取（％ID）与动脉粥样硬化中定量RAGE染色和％ID / g相关（R = 0.6887; P = 0.01）。结论这些结果支持了抑制RAGE对减少糖尿病的动脉粥样硬化并发症的重要性，并支持分子成像对评估治疗效果的价值。

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