Using both strands: The fundamental nature of antisense transcription

Struan C Murray; Jane Mellor

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Using both strands: The fundamental nature of antisense transcription

机译：使用两条链：反义转录的基本性质

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Non-coding transcription across the antisense strands of genes is an abundant, pervasive process in eukaryotes from yeast to humans, however its biological function remains elusive. Here, we provide commentary on a recent study of ours, which demonstrates a genome-wide role for antisense transcription: establishing a unique, dynamic chromatin architecture over genes. Antisense transcription increases the level of nucleosome occupancy and histone acetylation at the promoter and body of genes, withoutnecessarily modulating the level of protein-coding sense transcription. It is also associated with high levels of histone turnover. By allowing genes to sample a wider range of chromatin configurations, antisense transcription could serve to make genes more sensitive to changing signals, priming them for responses to developmental programs or stressful cellular environments. Given the abundance of antisense transcription and the breadth of these chromatin changes, we propose that antisense transcriptionrepresents a fundamental, canonical feature of eukaryotic genes.

机译：从酵母到人类的真核生物中，跨反义基因链的非编码转录是一个丰富而普遍的过程，但其生物学功能仍然难以捉摸。在这里，我们对我们最近的一项研究进行了评论，该研究证明了反义转录的全基因组作用：在基因上建立独特的动态染色质结构。反义转录增加了启动子和基因主体的核小体占有率和组蛋白乙酰化水平，而没有必要调节蛋白质编码正义转录的水平。它还与高水平的组蛋白周转有关。通过允许基因对更广泛的染色质配置进行采样，反义转录可以使基因对变化的信号更加敏感，从而为它们对发育程序或压力细胞环境的反应做好准备。鉴于反义转录的丰富性和这些染色质变化的广度，我们认为反义转录代表了真核基因的基本典型特征。

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来源
《BioArchitecture》 |2016年第1期|12-21|共10页
作者
Struan C Murray; Jane Mellor;
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作者单位

Department of Biochemistry,University of Oxford, Oxford, UK;

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原文格式 PDF
正文语种英语
中图分类普通生物学;
关键词
antisense transcription; chromatin dynamics; gene regulation; histone acetylation; nucleosomes; promoters;

机译：反义转录;染色质动力学;基因调控;组蛋白乙酰化;核小体;发起人;

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1. Head-to-head antisense transcription and R-loop formation promotes transcriptional activation [J] . Boque-Sastre Raquel, Soler Marta, Oliveira-Mateos CristinaPortela AnnaMoutinho CatiaSayols SergiVillanueva AlbertoEsteller ManelGuil Sonia Proceedings of the National Academy of Sciences of the United States of America . 2015,第18期

机译：Head-to-head antisense transcription and R-loop formation promotes transcriptional activation
2. Antisense-mediated FLC transcriptional repression requires the P-TEFb transcription elongation factor [J] . Zhi-Wei Wang, Zhe Wu, Oleg RaitskinQianwen SunCaroline Dean Proceedings of the National Academy of Sciences of the United States of America . 2014,第20期

机译：Antisense-mediated FLC transcriptional repression requires the P-TEFb transcription elongation factor
3. Evidence that the first strand-transfer reaction of duck hepatitis B virus reverse transcription requires the polymerase and that strand transfer is not needed for the switch of the polymerase to the elongation mode of DNA synthesis [J] . Gong YH., Stevens M., Tavis JE.Yao E. The Journal of General Virology: A Federation of European Miorobiological Societies Journal . 2000,第8期

机译：Evidence that the first strand-transfer reaction of duck hepatitis B virus reverse transcription requires the polymerase and that strand transfer is not needed for the switch of the polymerase to the elongation mode of DNA synthesis
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机译：用塞子的CCM自动启动STRAND STRAND：在盛开和平板脚轮上的应用
5. Fundamental Study on Particle Filtration Process and Gasoline Particulate Filter (GPF) Modeling =颗粒过滤的基础研究和汽油机尾气捕集器的建模 [D] . Yang, Yangdongfang. 2018

机译：Fundamental Study on Particle Filtration Process and Gasoline Particulate Filter (GPF) Modeling =颗粒过滤的基础研究和汽油机尾气捕集器的建模
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机译：勘误表：形态学和分子证据支持医学上重要的新蜘蛛Phoneutria的分类学分离脱蚁塔（Strand1909）和P.Boliviensis（F.O. Pickard-Cambridge1897）（阿兰西科斯蒂迪亚）。 Zookeys 1022：13-50。 https://doi.org/10.3897/zookeys.1022.60571
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机译：校正：用克里斯蒂安森A，Ahlstedt J，Holmqvist B，Brinte A，Tran Ta，Forssell-Aronsson E，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Trand Se，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Strand Se，Gram M Åkerströmb.抗氧化剂和氧化还原信号通知30：1746-1759,2017。Doi：10.1089 / Ars.2018.7517
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Using both strands: The fundamental nature of antisense transcription

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