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Age-specific effectiveness following each dose of acellular pertussis vaccine among infants and children in New Zealand

机译:新西兰婴儿和儿童每剂无细胞百日咳疫苗后的年龄特异性有效性

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Background: Though it is believed the switch from whole cell to acellular pertussis vaccine has contributed to the resurgence of pertussis disease, few studies have evaluated vaccine effectiveness (VE) and duration of protection provided by an acellular vaccine schedule including three primary doses but no toddler-age dose. We assessed this schedule in New Zealand (NZ), a setting with historically high rates of pertussis disease, and low but recently improved immunisation coverage. We further evaluated protection following the preschool-age booster dose.
机译:背景:尽管人们认为从全细胞到无细胞百日咳疫苗的转变导致了百日咳病的复发,但很少有研究评估疫苗有效性 (VE) 和无细胞疫苗计划提供的保护持续时间,包括三剂初级剂量但没有幼儿剂量。我们在新西兰(NZ)评估了这一时间表,新西兰的百日咳病发病率历来很高,免疫覆盖率低但最近有所改善。我们进一步评估了学龄前儿童加强剂量后的保护作用。

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