RNA-Binding Proteins Revisited - The Emerging Arabidopsis mRNA Interactome

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RNA-Binding Proteins Revisited - The Emerging Arabidopsis mRNA Interactome

机译：重新审视 RNA 结合蛋白 - 新兴的拟南芥 mRNA 相互作用组

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RNA-protein interaction is an important checkpoint to tune gene expression at the RNA level. Global identification of proteins binding in vivo to mRNA has been possible through interactome capture - where proteins are fixed to target RNAs by UV crosslinking and purified through affinity capture of polyadenylated RNA. In Arabidopsis over 500 RNA-binding proteins (RBPs) enriched in UV-crosslinked samples have been identified. As in mammals and yeast, the mRNA interactomes came with a few surprises. For example, a plethora of the proteins caught on RNA had not previously been linked to RNA-mediated processes, for example proteins of intermediary metabolism. Thus, the studies provide unprecedented insights into the composition of the mRNA interactome, highlighting the complexity of RNA-mediated processes.

机译：RNA-蛋白质相互作用是在RNA水平上调节基因表达的重要检查点。通过相互作用组捕获，可以全局鉴定体内与 mRNA 结合的蛋白质 - 其中蛋白质通过紫外交联固定到靶 RNA 上，并通过多聚腺苷酸化 RNA 的亲和捕获进行纯化。在拟南芥中，已经鉴定出 500 多种富含紫外交联样品的 RNA 结合蛋白（RBP）。与哺乳动物和酵母一样，mRNA相互作用组也带来了一些惊喜。例如，在RNA上捕获的大量蛋白质以前没有与RNA介导的过程有关，例如中间代谢的蛋白质。因此，这些研究为mRNA相互作用组的组成提供了前所未有的见解，突出了RNA介导过程的复杂性。

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《Trends in Plant Science》 |2017年第6期|512-526|共15页
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正文语种英语
中图分类植物学;
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1. The PPR protein PDM1 is involved in the processing of rpoA pre-mRNA in Arabidopsis thaliana [J] . WU Hao, ZHANG LiXin 中国科学通报：英文版 . 2010,第30期
2. Detection of viral protein–protein interaction by microplate-format luminescence-based mammalian interactome mapping（LUMIER） [J] . Qiji Deng, Dan Wang, Feng Li 中国病毒学：英文版 . 2014,第3期
3. RNA interactome capture in Escherichia coli globally identifies RNA-binding proteins [J] . Stenum Thomas Sondergaard, Kumar Ankith D., Sandbaumhueter Friederike A.Kjellin JonasJerlstrom-Hultqvist JonAndren Per E.Koskiniemi SannaJansson Erik T.Holmqvist Erik Nucleic Acids Research . 2023,第9期

机译：RNA interactome capture in Escherichia coli globally identifies RNA-binding proteins
4. RNA-dependent interactome allows network-based assignment of RNA-binding protein function [J] . Fradera-Sola Albert, Nischwitz Emily, Bayer Marie ElisabethLuck KatjaButter Falk Nucleic Acids Research . 2023,第10期

机译：RNA-dependent interactome allows network-based assignment of RNA-binding protein function
5. Targeted Endoplasmic Reticulum Localization of Storage Protein mRNAs Requires the RNA-Binding Protein RBP-L [J] . Tian Li, Chou Hong-Li, Zhang LainingOkita Thomas W. Plant physiology . 2019,第3期

机译：Targeted Endoplasmic Reticulum Localization of Storage Protein mRNAs Requires the RNA-Binding Protein RBP-L
6. Role of Arabidopsis Splicing factor SF1 in Temperature-Responsive Alternative Splicing of FLM pre-mRNA [O] . Keh Chien Lee, Kyung Sook Chung, Hee Tae Lee, 2020

机译：Arabidopsis剪接因子SF1在FLM前mRNA温度响应替代剪接中的作用
7. An Effector of RNA-Directed DNA Methylation in Arabidopsis Is an ARGONAUTE 4-and RNA-Binding Protein [O] . He, X.J., Hsu, Y.F., Zhu, S.H., 2014

机译：an Effector of RNa-Directed DNa methylation in arabidopsis Is an aRGONaUTE 4-and RNa-Binding protein

RNA-Binding Proteins Revisited - The Emerging Arabidopsis mRNA Interactome

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