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首页> 外文期刊>Vaccine >Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine
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Protective immunity to H7N9 influenza viruses elicited by synthetic DNA vaccine

机译：对合成DNA疫苗引发的H7N9流感病毒的保护性免疫

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Despite an intensive vaccine program influenza infections remain a major health problem, due to the viruses' ability to change its envelope glycoprotein hemagglutinin (HA), through shift and drift, permitting influenza to escape protection induced by current vaccines or natural immunity. Recently a new variant, H7N9, has emerged in China causing global concern. First, there have been more than 130 laboratory-confirmed human infections resulting in an alarmingly high death rate (32.3). Second, genetic changes found in H7N9 appear to be associated with enabling avian influenza viruses to spread more effectively in mammals, thus transmitting infections on a larger scale. Currently, no vaccines or drugs are effectively able to target H7N9. Here, we report the rapid development of a synthetic consensus DNA vaccine (pH7HA) to elicit potent protective immunity against the H7N9 viruses. We show that pH7HA induces broad antibody responses that bind to divergent HAs from multiple new members of the H7N9 family. These antibody responses result in high-titer HAI against H7N9. Simultaneously, this vaccine induces potent polyfunctional effector CD4 and CD8T cell memory responses. Animals vaccinated with pH7HA are completely protected from H7N9 virus infection and any morbidity associated with lethal challenge. This study establishes that this synthetic consensus DNA vaccine represents a new tool for targeting emerging infection, and more importantly, its design, testing and development into seed stock for vaccine production in a few days in the pandemic setting has significant implications for the rapid deployment of vaccines protecting against emerging infectious diseases
机译：尽管实施了密集的疫苗计划，但流感感染仍然是一个主要的健康问题，因为病毒能够通过转移和漂移改变其包膜糖蛋白血凝素 （HA），从而使流感逃避当前疫苗或自然免疫诱导的保护。最近，中国出现了一种新的变种H7N9，引起了全球的关注。首先，有130多例实验室确诊的人感染，导致死亡率高得惊人（32.3%）。其次，在H7N9中发现的遗传变化似乎与禽流感病毒在哺乳动物中更有效地传播有关，从而在更大范围内传播感染。目前，没有疫苗或药物能够有效地针对H7N9。在这里，我们报告了合成共识DNA疫苗（pH7HA）的快速发展，以引发针对H7N9病毒的有效保护性免疫。我们发现 pH7HA 诱导广泛的抗体反应，这些抗体反应与来自 H7N9 家族多个新成员的不同 HA 结合。这些抗体反应导致针对 H7N9 的高滴度 HAI。同时，该疫苗诱导有效的多功能效应 CD4 和 CD8T 细胞记忆反应。接种了pH7HA疫苗的动物可以完全免受H7N9病毒感染和任何与致命攻击相关的发病率。本研究表明，这种合成的共识DNA疫苗代表了一种针对新发感染的新工具，更重要的是，它在大流行背景下几天内设计、测试和开发成疫苗生产的种子库，对快速部署预防新发传染病的疫苗具有重大意义

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