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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Simultaneous extraction of acidic and basic drugs at neutral sample pH: A novel electro-mediated microextraction approach
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Simultaneous extraction of acidic and basic drugs at neutral sample pH: A novel electro-mediated microextraction approach

机译：在中性样品pH值下同时提取酸性和碱性药物：一种新的电介导微萃取方法

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摘要

The simultaneous extraction of acidic and basic analytes from a particular sample is a challenging task. In this work, electromembrane extraction (EME) of acidic non-steroidal anti-inflammatory drugs and basic β-blockers in a single step was carried out for the first time. It was shown that by designing an appropriate compartmentalized membrane envelope, the two classes of drugs could be electrokinetically extracted by a 300V direct current electrical potential. This method required only a very short 10-min extraction time from a pH-neutral sample, with a small amount (50μL) of organic solvent (1-octanol) as the acceptor phase. Analysis was carried out using gas chromatography-mass spectrometry after derivatization of the analytes. Extraction parameters such as extraction time, applied voltage, pH range, and concentration of salt added were optimized. The proposed EME technique provided good linearity with correlation coefficients from 0.982 to 0.997 over a concentration range of 1-200μgL~(-1). Detection limits of the drugs ranged between 0.0081 and 0.26μgL~(-1), while reproducibility ranged from 6 to 13 (n=6). Finally, the application of the new method to wastewater samples was demonstrated.
机译：从特定样品中同时提取酸性和碱性分析物是一项具有挑战性的任务。本工作首次对酸性非甾体抗炎药和碱性β阻滞剂进行电膜提取（EME）。结果表明，通过设计适当的分隔膜包络，可以通过300V直流电势对两类药物进行电动萃取。该方法只需从pH中性样品中提取非常短的10分钟时间，使用少量（50μL）有机溶剂（1-辛醇）作为受体相。分析物衍生化后，使用气相色谱-质谱法进行分析。优化提取时间、施加电压、pH范围和添加盐浓度等提取参数。所提出的EME技术在1-200μgL~（-1）的浓度范围内具有良好的线性，相关系数为0.982-0.997。药物检出限在0.0081-0.26μgL~（-1）之间，重现性在6-13%之间（n=6）。最后，论证了新方法在废水样品中的应用。

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