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首页> 外文期刊>Trends in Plant Science >PCI complexes: pretty complex interactions in diverse signaling pathwaysReview
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PCI complexes: pretty complex interactions in diverse signaling pathwaysReview

机译:PCI复合物:不同信号通路中相当复杂的相互作用评论

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摘要

Three protein complexes (the proteasome regulatory lid, the COP9 signalosome and eukaryotic translation initiation factor 3) contain protein subunits with a well defined protein domain, the PCI domain. At least two (the COP9 signalosome and the lid) appear to share a common evolutionary origin. Recent advances in our understanding of the structure and function of the three complexes point to intriguing and unanticipated connections between the cellular functions performed by these three protein assemblies, especially between translation initiation and proteolytic protein degradation.
机译:三种蛋白质复合物(蛋白酶体调节盖、COP9 信号体和真核翻译起始因子 3)包含具有明确定义蛋白质结构域的蛋白质亚基,即 PCI 结构域。至少有两个(COP9信号体和盖子)似乎具有共同的进化起源。我们对这三种复合物的结构和功能的理解的最新进展表明,这三种蛋白质组装体执行的细胞功能之间存在有趣且意想不到的联系,尤其是翻译起始和蛋白水解蛋白降解之间的联系。

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