Aminopeptidases of Malaria Parasites: New Targets for Chemotherapy

Katharine R. Trenholme; Christopher L. Brown; Tina S. Skinner Adams Colin Stack Jonathan Lowther Joyce To Mark W. Robinson Sheila M. Donnelly John P. Dalton Donald L.Gardiner

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Aminopeptidases of Malaria Parasites: New Targets for Chemotherapy

机译：疟疾寄生虫的氨肽酶：化疗的新靶点

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Novel targets for new drug development are urgently required to combat malaria, a disease that puts half of the world's population at risk. One group of enzymes identified within the genome of the most lethal of the causative agents of malaria, Plasmodium falciparum, that may have the potential to become new targets for antimalarial drug development are the aminopeptidases. These enzymes catalyse the cleavage of the N-terminal amino acids from proteins and peptides. P. falciparum appears to encode for at least nine aminopeptidases, two neutral aminopeptidases, one aspartyl aminopeptidase, one aminopeptidase P, one prolyl aminopeptidase and four methionine aminopeptidases. Recent advances in our understanding of these genes and their protein products are outlined in this review, including their potential for antimalarial drug development.

机译：为了抗击疟疾，迫切需要新药开发的新靶点，疟疾是一种使世界一半人口处于危险之中的疾病。在最致命的疟疾病原体恶性疟原虫基因组中发现的一组酶有可能成为抗疟药物开发的新靶点，即氨肽酶。这些酶催化蛋白质和肽中 N 端氨基酸的裂解。恶性疟原虫似乎编码至少九种氨基肽酶、两种中性氨基肽酶、一种天冬氨酰氨肽酶、一种氨肽酶 P、一种脯氨酰氨肽酶和四种蛋氨酸氨肽酶。本综述概述了我们对这些基因及其蛋白质产物的理解的最新进展，包括它们在抗疟药物开发方面的潜力。

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来源
《Infectious disorders drug targets》 |2010年第3期|217-225|共9页
作者
Katharine R. Trenholme; Christopher L. Brown; Tina S. Skinner Adams Colin Stack Jonathan Lowther Joyce To Mark W. Robinson Sheila M. Donnelly John P. Dalton Donald L.Gardiner;
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作者单位

Malaria Biology Laboratory, Queensland Institute of Medical Research, 300 Herston Rd, Herston, QLD, 4006. Australia;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Plasmodium falciparum; malaria; aminopeptidase; drug discovery.;

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机译：Iniciativa presidencial Contra a malaria：mantendo o momento Contra a malaria。 salvando Vidas非洲。 Quarto Relatorio anual，abril de 2010. sumario Executivo（总统的疟疾倡议：维持抗疟疾的势头。拯救非洲的生命。第四次年度报告，2010年4月。执行摘要）

Aminopeptidases of Malaria Parasites: New Targets for Chemotherapy

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