...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Current Molecular Biology Reports >Targeting the Stem Cell Properties of Adult Breast Cancer Cells: Using Combinatorial Strategies to Overcome Drug Resistance
【24h】

Targeting the Stem Cell Properties of Adult Breast Cancer Cells: Using Combinatorial Strategies to Overcome Drug Resistance

机译：靶向成人乳腺癌细胞的干细胞特性：使用组合策略克服耐药性

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose of Review Cancer is a major public health problem worldwide. In aggressive cancers, which are heterogeneous in nature, there exists a paucity of targetable molecules that can be used to predict outcome and response to therapy in patients, especially those in the high-risk category with a propensity to relapse following chemotherapy. This review addresses the challenges pertinent to treating aggressive cancer cells with inherent stem cell properties, with a special focus on triple-negative breast cancer (TNBC).Recent Findings Plasticity underlies the cancer stem cell (CSC) phenotype in aggressive cancers like TNBC. Progenitors and CSCs implement similar signaling pathways to sustain growth, and the convergence of embryonic andtumorigenic signaling pathways has led to the discovery of novel oncofetal targets, rigorously regulated during normal development, but aberrantly reactivated in aggressive forms of cancer.Summary Translational studies have shown that Nodal, an embryonic morphogen, is reactivated in aggressive cancers, but not in normal tissues, and underlies tumor growth, invasion, metastasis, and drug resistance. Front-line therapies do not inhibit Nodal, but when a combinatorial approach is used with an agent such as doxorubicin followed by anti-Nodal antibody therapy, significant decreases in cell growth and viability occur. These findings are of special interest in the development of new therapeuticinterventions that target the stem cell properties of cancer cells to overcome drug resistance and metastasis.
机译：综述目的 癌症是世界范围内一个重大的公共卫生问题。在本质上是异质性的侵袭性癌症中，缺乏可用于预测患者治疗结果和治疗反应的靶向分子，尤其是那些化疗后有复发倾向的高危人群。本综述探讨了与治疗具有固有干细胞特性的侵袭性癌细胞相关的挑战，特别关注三阴性乳腺癌（TNBC）。最近的发现 可塑性是 TNBC 等侵袭性癌症中癌症干细胞 （CSC） 表型的基础。祖细胞和CSC实现相似的信号通路以维持生长，胚胎和致瘤性信号通路的融合导致了新的癌胎靶标的发现，这些靶标在正常发育过程中受到严格调节，但在侵袭性癌症中异常重新激活。转化研究表明，Nodal 是一种胚胎形态原，在侵袭性癌症中被重新激活，但在正常组织中则不然，并且是肿瘤生长、侵袭、转移和耐药性的基础。一线治疗不会抑制淋巴结，但当联合方法与阿霉素等药物联合使用，然后进行抗淋巴结抗体治疗时，细胞生长和活力显着降低。这些发现对开发新的治疗干预措施特别感兴趣，这些干预措施针对癌细胞的干细胞特性以克服耐药性和转移。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号