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首页> 外文期刊>International review of cytology >The mannose receptor in the brain.
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The mannose receptor in the brain.

机译：大脑中的甘露糖受体。

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摘要

The mannose receptor is a transmembrane glycoprotein mainly expressed by macrophages, that specifically binds to mannosylated molecules and mediates their endocytosis. Known ligands of the receptor are lysosomases and various pathogens. Ligand specificity and cellular distribution provide the mannose receptor with a very important role in homeostasis and in the immune response. Expression of the mannose receptor has recently been demonstrated in the brain. Astrocytes and microglia, two types of glial cells that can be turned into immune-competent cells, are the main site of expression in vivo and in vitro. The mannose receptor mediates in vitro pinocytosis by astrocytes and microglia and phagocytosis by microglia. Expression and endocytic activities of the mannose receptor in these cells are regulated by various cytokines. Based on our current knowledge on mannose receptor activities in brain cells, on its regional and temporal expression in that organ, and on its putative ligands therein, the possibleinvolvement of the mannose receptor in brain homeostasis, neuronal functions, and brain defense is discussed.
机译：甘露糖受体是主要由巨噬细胞表达的跨膜糖蛋白，其特异性结合甘露糖基化分子并介导其内吞作用。受体的已知配体是溶血酶和各种病原体。配体特异性和细胞分布为甘露糖受体在体内平衡和免疫应答中起着非常重要的作用。最近已经在大脑中证明了甘露糖受体的表达。星形胶质细胞和小胶质细胞是两种可以转化为具有免疫能力的细胞，是体内和体外表达的主要部位。甘露糖受体通过星形胶质细胞和小胶质细胞介导体外胞吞作用，并通过小胶质细胞吞噬作用。这些细胞中甘露糖受体的表达和内吞活性受多种细胞因子调节。基于我们目前对脑细胞中甘露糖受体活性，在该器官中的区域和时间表达以及其中假定的配体的了解，讨论了甘露糖受体可能参与脑稳态，神经元功能和脑防御。

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