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首页> 外文期刊>Pain management nursing: official journal of the American Society of Pain Management Nurses >Capsaicin 8 Dermal Patch for Neuropathic Pain in a Pain Unit
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Capsaicin 8 Dermal Patch for Neuropathic Pain in a Pain Unit

机译：辣椒素 8 真皮贴剂用于疼痛单位的神经性疼痛

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? 2022 American Society for Pain Management NursingAims: Pain units manage approximately 20 of the patients with neuropathic pain, usually presenting with severe uncontrolled pain associated with substantial impairment of quality-of-life and disability. We aimed to analyze the experience with the capsaicin 8 dermal patch for managing patients with neuropathic pain in a pain unit. Design: This was a post-authorization observational and retrospective study conducted at a single pain unit on patients with peripheral neuropathic pain under routine clinical care. Methods: Diagnosis of neuropathic pain was based on the Douleur Neuropathique 4 (DN4) questionnaire. Evaluations included pain intensity according to a visual analog scale and the quality-of-life as evaluated with the European Quality of Life-5 Dimensions (EQ-5D). Results: We included 66 patients with neuropathic pain lasting for a median of 24 months. The most frequent diagnosis was iatrogenic neuropathic pain (47) and two thirds of patients exhibited extreme pain or discomfort. Pain intensity was reduced significantly from a mean (standard deviation SD) of 7.20 (1.95) at baseline to 6.02 (2.77) at month 3, leading to a mean change from baseline of 1.19 (95 confidence interval CI, 0.59 to 1.78; p < .001; Cohen's d 0.49). The extent of the pain area was also significantly reduced from a median (interquartile range IQR) of 169.5 cm2 (69.3-299.9) at baseline to 121.2 cm2 (35.4-183.9) at month 3 (p < .001). There was an improvement in most dimensions of quality-of-life, especially regarding “usual activities,” “pain/discomfort,” and “anxiety/depression.” Tolerability was consistent with the known profile. Conclusions: Our results suggest that the capsaicin 8 dermal patch is a useful and well-tolerated treatment option for managing peripheral neuropathic pain in pain units.
机译：?2022 年美国疼痛管理护理学会目标：疼痛科管理大约 20% 的神经性疼痛患者，通常表现为严重的不受控制的疼痛，伴有生活质量和残疾的严重损害。我们旨在分析辣椒素 8% 真皮贴剂在疼痛病房治疗神经性疼痛患者的经验。设计：这是一项在单个疼痛病房对常规临床护理下的周围神经性疼痛患者进行的授权后观察性和回顾性研究。方法：神经性疼痛的诊断基于Douleur Neuropathique 4（DN4）问卷。评估包括根据视觉模拟量表的疼痛强度和使用欧洲生活质量 5 维度 （EQ-5D） 评估的生活质量。结果：我们纳入了 66 例中位持续 24 个月的神经性疼痛患者。最常见的诊断是医源性神经性疼痛（47%），三分之二的患者表现出极度疼痛或不适。疼痛强度从基线时的平均值（标准差 [SD]）7.20 （1.95） 显着降低到第 3 个月的 6.02 （2.77），导致平均值相对于基线的变化为 1.19（95% 置信区间 [CI]，0.59 至 1.78;p < .001;科恩的d 0.49）。疼痛区域的范围也从基线时的中位数（四分位距 [IQR]）的 169.5 cm2 （69.3-299.9） 显着降低到第 3 个月的 121.2 cm2 （35.4-183.9） （p < .001）。生活质量的大多数方面都有所改善，特别是在“日常活动”、“疼痛/不适”和“焦虑/抑郁”方面。耐受性与已知特征一致。结论：我们的研究结果表明，辣椒素 8% 真皮贴剂是治疗疼痛单位周围神经性疼痛的有用且耐受性良好的治疗选择。

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