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Cosmetic Botulinum Neurotoxin Application

机译：化妆品肉毒杆菌神经毒素的应用

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摘要

One of the safest, simplest, and most satisfying methods of elective cosmetic reduction of facial rhytides is by the injection of botulinum neurotoxin type A (BoNT-A). BoNT-A is currently injected into selected superficial musculoaponeurotic system (SMAS) type facial muscles to temporarily reduce associated static and dynamic wrinkles, BoNT-A relaxes muscles by preventing the presynaptic release of the neurotransmitter acetylcholine (ACh) at the peripheral cholinergic motor neuron end plate. ACh is stored in vesicles residing in the motor nerve ending Docking is a necessary step before release of ACh into the neuromuscular junction. BoNT-A prevents the docking and exocytosis of these ACh vesicles to the nerve end plate, In order for BoNT-A to exert this effect, it must first be absorbed into the nerve ending by a process termed receptor-mediated endocytosis. After BoNT-A is internalized within a cytoplasmic vesicle, the light chain is released into the cytoplasm. The light chain cleaves a protein known as SNAP-25A, which must be functional in order for ACh vesicles to dock before release into the neuromuscular junction.
机译：选择性减少面部除皱的最安全，最简单和最令人满意的方法之一是注射A型肉毒杆菌神经毒素（BoNT-A）。 BoNT-A目前已注射到选定的浅表肌腱膜系统（SMAS）型面部肌肉中，以暂时减少相关的静态和动态皱纹，BoNT-A通过阻止神经递质乙酰胆碱（ACh）在周围胆碱能运动神经元末端的突触前释放来放松肌肉。盘子。 ACh存储在运动神经末梢的囊泡中。将ACh释放到神经肌肉接头之前，对接是必要的步骤。 BoNT-A阻止了这些ACh囊泡对接和胞吐到神经终板。为了使BoNT-A发挥这种作用，必须首先通过称为受体介导的内吞作用的过程将其吸收到神经末梢。 BoNT-A被内化到细胞质囊泡中后，轻链被释放到细胞质中。轻链裂解了一种称为SNAP-25A的蛋白质，该蛋白质必须起作用才能使ACh囊泡在释放到神经肌肉接头之前停靠。

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