The Effect of Salinomycin on Ganglioside Production in Lead-Intoxicated Mice. An Immunological Study

Vera Kolyovska; Juliana Ivanova; Emilia PetrovaYordanka GluhchevaEkaterina Pavlova

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The Effect of Salinomycin on Ganglioside Production in Lead-Intoxicated Mice. An Immunological Study

机译：盐霉素对铅中毒小鼠神经节苷脂产生的影响。免疫学研究

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GM3 gangliosides have been described as biomarkers for oncogenic tissue changes. Anti-GM3 antibodies in mouse sera were tested in a lead intoxication model, followed by treatment with the polyether ionophorous antibiotic salinomycin. The results show abiding high titer of IgG antibodies against the GM3 gangliosides only in sera from salinomycin-treated mice. It could be concluded that the high titer of anti-GM3 antibodies is associated with signs of oncogenity.

机译：GM3 神经节苷脂已被描述为致癌组织变化的生物标志物。在先导化合物中毒模型中测试小鼠血清中的抗 GM3 抗体，然后用聚醚离子抗生素盐霉素处理。结果显示，仅在盐霉素处理的小鼠血清中，针对 GM3 神经节苷脂的 IgG 抗体具有持久的高滴度。可以得出结论，抗 GM3 抗体的高滴度与致癌体征有关。

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《Acta morphologica et anthropologica》 |2018年第4期|71-75|共5页
作者
Vera Kolyovska; Juliana Ivanova; Emilia PetrovaYordanka GluhchevaEkaterina Pavlova;
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作者单位

Institute of Experimental Morphology, Pathology and Anthropology with Museum, Bulgarian Academy of Sciences, Sofia, Bulgaria;

Faculty of Medicine, Sofia University "St. Kliment Ohridski", Sofia, Bulgaria;

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原文格式 PDF
正文语种英语
中图分类细胞生物学;
关键词
salinomycin; anti-GM3 ganglioside antibodies; lead intoxication;

机译：盐霉素;抗GM3神经节苷脂抗体;铅中毒;

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The Effect of Salinomycin on Ganglioside Production in Lead-Intoxicated Mice. An Immunological Study

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