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首页> 外文期刊>Biomechanics and modeling in mechanobiology >Mechanics of the urethral duct: tissue constitutive formulation and structural modeling for the investigation of lumen occlusion
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Mechanics of the urethral duct: tissue constitutive formulation and structural modeling for the investigation of lumen occlusion

机译：尿道管的力学：用于研究管腔闭塞的组织组成型和结构建模

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摘要

Urinary incontinence, often related to sphincter damage, is found in male patients, leading to a miserable quality of life and to huge costs for the healthcare system. The most effective surgical solution currently considered for men is the artificial urinary sphincter that exerts a pressure field on the urethra, occluding the duct. The evaluation of this device is currently based on clinical and surgical competences. The artificial sphincter design and mechanical action can be investigated by a biomechanical model of the urethra under occlusion, evaluating the interaction between tissues and prosthesis. A specific computational approach to urethral mechanics is here proposed, recalling the results of previous biomechanical experimental investigation. In this preliminary analysis, the horse urethra is considered, in the light of a significant correlation with human and in consideration of the relevant difficulty to get to human samples, which anyway represents the future advance. Histological data processing allow for the definition of a virtual and a subsequent finite element model of a urethral section. A specific hyperelastic formulation is developed to characterize the nonlinear mechanical behavior. The inverse analysis of tensile tests on urethra samples leads to the definition of preliminary constitutive parameters. The parameters are further refined by the computational analysis of inflation tests carried out on the entire urethral structure. The results obtained represent, in the light of the correlation reported, a valid preliminary support for the information to be assumed for prosthesis design, integrating surgical and biomechanical competences.
机译：尿失禁通常与括约肌损伤有关，见于男性患者，导致生活质量低下，给医疗保健系统带来巨额成本。目前考虑的男性最有效的手术解决方案是人工尿道括约肌，它对尿道施加压力场，阻塞导管。该设备的评估目前基于临床和手术能力。人工括约肌的设计和机械作用可以通过闭塞下尿道的生物力学模型进行研究，评估组织与假体之间的相互作用。本文提出了一种特定的尿道力学计算方法，回顾了先前生物力学实验研究的结果。在这项初步分析中，考虑到马尿道与人类的显着相关性，并考虑到获得人类样本的相关困难，这无论如何都代表了未来的进步。组织学数据处理允许定义尿道切片的虚拟模型和随后的有限元模型。开发了一种特定的超弹性公式来表征非线性力学行为。对尿道样品进行拉伸试验的反向分析导致了初步本构参数的定义。通过对整个尿道结构进行的充气测试的计算分析，进一步完善了参数。根据所报告的相关性，所获得的结果代表了对假肢设计所假设的信息的有效初步支持，整合了手术和生物力学能力。

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