Alternative phospholipase D/mTOR survival signal in human breast cancer cells.

Chen Y; Rodrik V; Foster DA

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Alternative phospholipase D/mTOR survival signal in human breast cancer cells.

机译：人乳腺癌细胞中的替代磷脂酶 D/mTOR 存活信号。

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Cancer cells generate survival signals to suppress default apoptotic programs that protect from cancer. Phosphatidylinositol-3-kinase (PI3K) generates a survival signal that is frequently dysregulated in human cancers. Phospholipase D (PLD) has also been implicated in signals that promote survival. One of the targets of PLD signaling is mTOR (mammalian target of rapamycin), a critical regulator of cell cycle progression and cell growth. We report here that elevated PLD activity in the MDA-MB-231 human breast cancer cell line generates an mTOR-dependent survival signal that is independent of PI3K. In contrast, MDA-MB-435S breast cancer cells, which have very low levels of PLD activity, are dependent on PI3K for survival signals. The data presented here identify an alternative survival signal that is dependent on PLD and mTOR and is active in a breast cancer cell line where the PI3K survival pathway is not active.

机译：癌细胞产生存活信号以抑制预防癌症的默认凋亡程序。磷脂酰肌醇-3-激酶（PI3K）产生一种生存信号，该信号在人类癌症中经常失调。磷脂酶 D （PLD）也与促进生存的信号有关。PLD 信号转导的靶标之一是 mTOR（雷帕霉素的哺乳动物靶标），它是细胞周期进程和细胞生长的关键调节因子。我们在这里报告说，MDA-MB-231 人乳腺癌细胞系中 PLD 活性升高会产生独立于 PI3K 的 mTOR 依赖性生存信号。相比之下，MDA-MB-435S 乳腺癌细胞具有非常低的 PLD 活性水平，依赖于 PI3K 的生存信号。这里提供的数据确定了一种替代生存信号，该信号依赖于 PLD 和 mTOR，并且在 PI3K 存活途径不活跃的乳腺癌细胞系中具有活性。

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《Oncogene》 |2005年第4期|672-679|共8页
作者
Chen Y; Rodrik V; Foster DA;
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作者单位

Department of Biological Sciences, Hunter College of The City University of New York, New York, NY 10021, USA.;

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原文格式 PDF
正文语种英语
中图分类肿瘤学;
关键词
Breast Neoplasms; Phospholipase D; Protein Kinases; Signal Transduction; 乳腺肿瘤; 磷脂酶D; 蛋白激酶类; 信号传递;

机译：乳腺肿瘤;磷脂酶 D;蛋白激酶;信号转导;乳腺肿瘤;磷脂酶D;蛋白激酶类;信号传递;

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Alternative phospholipase D/mTOR survival signal in human breast cancer cells.

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