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Applying Bayesian ideas in drug development and clinical trials

机译：在药物开发和临床试验中应用贝叶斯思想

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AbstractThe Bayesian paradigm emphasizes that studies are not performed in isolation, and that external evidence can be used formally in the design, monitoring and reporting of clinical trials. A variety of tools for assessing the current evidence for treatment efficacy are presented, making use of graphical display to provide insight into ethical and efficiency issues in starting and stopping trials – these are illustrated with a trial in osteosarcoma that is currently taking place. Finally we recommend that an additional ‘interpretation’ section is placed in clinical reports to provide a bridge between ‘results’ and ‘discussion’ – it is this section that would contain the Bayes
机译：摘要贝叶斯范式强调研究不是孤立进行的，外部证据可以正式用于临床试验的设计、监测和报告。介绍了用于评估当前治疗效果证据的各种工具，利用图形显示来深入了解启动和停止试验的伦理和效率问题——目前正在进行的骨肉瘤试验说明了这些问题。最后，我们建议在临床报告中增加一个“解释”部分，以在“结果”和“讨论”之间架起一座桥梁——正是这一部分将包含贝叶斯

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