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首页> 外文期刊>International journal of surgical pathology >Prognostic Significance of Lymphatic Vessel Density Detected by D2-40 and Its Relation to Claudin-4 Expression in Prostatic Adenocarcinoma
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Prognostic Significance of Lymphatic Vessel Density Detected by D2-40 and Its Relation to Claudin-4 Expression in Prostatic Adenocarcinoma

机译：D2-40检测的淋巴管密度在前列腺腺癌中的预后意义及其与Claudin-4表达的关系

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Background. Lymphovascular invasion is an important pathway of metastatic spread and regional lymph node metastasis is the major prognostic factor in prostatic adenocarcinoma. D2-40 is used to identify the lymphatic vessels and to assess the lymphatic vessel density (LVD). Expression of claudin-4 may be related to invasion and progression of carcinoma cells in several primary tumors. Aim. To evaluate intra- and peritumoral LVD through immunohistochemical expression of D2-40 in relation to claudin-4 expression and clinicopathological parameters in prostatic adenocarcinoma. Materials and Methods. Immunohistochemical staining procedure was performed on 53 paraffin-embedded blocks of radical prostatectomy specimens for prostatic adenocarcinoma using anti D2-40 and claudin-4 antibodies. Sections were evaluated for mean LVD in intratumoral and peritumoral tissues assessed by D2-40 expression. Results. LVD in intratumoral tissues was significantly lower compared with peritumoral areas (P = .0001). Peritumoral mean LVD was significantly higher in cases with lymphovascular invasion (P = .041) and in cases with positive lymph node metastasis (P = .003) than intratumoral mean LVD. High claudin-4 expression was significantly correlated with high tumor grade (P = .0001), lymphovascular invasion (P = .006), and positive lymph node metastasis (P = .004). High claudin-4 expression was significantly associated with increased mean LVD in peritumoral tissues. Conclusion. Increased peritumoral mean LVD in prostatic adenocarcinoma is associated with lymphovascular invasion and positive lymph node metastasis. High claudin-4 expression is associated with high tumor grade, lymphocascular invasion, positive lymph node metastasis, and high mean peritumoral LVD suggesting that D2-40 and claudin-4 may represent different mechanisms of lymphatic vessel invasion with both biomarkers is related to poor prognosis.
机译：背景。淋巴管浸润是转移性扩散的重要途径，区域淋巴结转移是前列腺癌的主要预后因素。 D2-40用于识别淋巴管并评估淋巴管密度（LVD）。 claudin-4的表达可能与几种原发性肿瘤中癌细胞的侵袭和进展有关。目标。通过D2-40的免疫组织化学表达与前列腺癌中claudin-4的表达和临床病理参数的比较，评估肿瘤内和肿瘤周围的LVD。材料和方法。使用抗D2-40和claudin-4抗体对53例前列腺癌根治性前列腺切除术标本中石蜡包埋的块进行免疫组织化学染色。通过D2-40表达评估切片在肿瘤内和肿瘤周围组织中的平均LVD。结果。与肿瘤周围区域相比，肿瘤内组织中的LVD显着降低（P = .0001）。淋巴管浸润（P = .041）和淋巴结转移阳性（P = .003）的病例的周平均LVD明显高于瘤内平均LVD。 claudin-4的高表达与高肿瘤分级（P = .0001），淋巴管浸润（P = .006）和阳性淋巴结转移（P = .004）显着相关。 claudin-4高表达与肿瘤周围组织中平均LVD升高显着相关。结论。前列腺癌的瘤周平均LVD升高与淋巴管浸润和淋巴结转移阳性有关。 claudin-4的高表达与肿瘤的高分级，淋巴管浸润，淋巴结转移阳性和平均LVD高有关，提示D2-40和claudin-4可能代表淋巴管浸润的不同机制，这两种生物标志物均与不良预后相关。 。

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